重组组织型纤溶酶原激活剂与尿激酶溶栓治疗急性心肌梗死的疗效比较  

The Efficacy of Thrombolytic Therapy with Recombinant Tissue Plasminogen Activator as Compared with urokinase for Acute Myocardial Infarction

作　　者：王志男[1] 雷力成[1] 

机构地区：[1]北京市铁路总医院心内科,100038

出　　处：《中国误诊学杂志》2001年第6期813-815,共3页Chinese Journal of Misdiagnostics

摘　　要：目的　观察小剂量 (5 0 mg)重组织型纤溶酶原激活剂 (rt- PA)与尿激酶 (UK)溶栓治疗急性心肌梗死(AMI)的疗效及安全性。方法　将 116例 AMI患者随机分为 rt- PA组和 U K组 ,分别应用 rt- PA和 UK溶栓治疗。结果　冠状动脉 (冠脉 )总再通率分别 rt- PA组 80 .6 5 %和 UK组为 5 1.85 % ;患者在发病后 6 h内治疗 ,冠脉再通率分别为 rt-PA组 91.18%和 UK组 6 7.86 % ,前者明显高于后者 ,两组比较均有显著差异 (P<0 .0 1)。 5 wk住院病死率分别为 rt- PA组 6 .5 %和 UK组 11.1%。结论　小剂量 (5 0 mg) rt- PA用于 AMI溶栓治疗的临床疗效明显优于 UK,血管再通率高 ,尤其在发病后 6 h内进行治疗效果更佳 ;rt- PA溶栓并发症少 ,可降低病死率 ,是一种安全有效的溶栓剂。Objective To observe the effect and safety of thrombolytic therapy with low dose recombinant tissue plasminogen activator (rt-PA) as compared with urokinase (UK) for acute myocardial infarction (AMI).Methods 116 patients with AMI were divided into rt-PA group and UK group,which were treated with low dose rt-PA and UK respectively.Results The total reperfusion rate was 80.65% in rt-PA group,and 51.85% in UK group.When thrombolysis was given in 6 hours from symptom onset,the reperfusion rate was significant higher in rt-PA group than that in UK group.(91.18% vs.66.86%).P<0.01.The mortality during 5-week hospitalization was 6.5% (rt-PA group) vs.11.1% (UK group).Conclusions Thrombolytic therapy with low dose (50 mg) rt-PA is significantly more efficacious than that with UK,with higher rate of reperfusion,especially in 6 hours after morbility,and the mortality can be reduced and complications appear to be decreased in rt-PA group.The data above indicates that rt-PA is effective and safe in thrombolytic therapy for acute myocardial infarction.

关 键 词：急性心肌梗死 重组组织型纤维酶原激活剂 尿激酶 溶栓疗法 疗效 

分 类 号：R542.22[医药卫生—心血管疾病]