羟基磷灰石生物涂层的复合制备与生物相容性  

Duplex Prepared Hydroxyapatite Coating and Its Biocompatibility

作　　者：付涛[1] 张玉梅[2] 憨勇[1] 徐可为[1] XU Ke-Wei 

机构地区：[1]西安交通大学金属材料强度国家重点实验室,西安710049 [2]西安交通大学,第四军医大学口腔医院修复科 [3]State Key Laboratory for Mechenical Behavior of Materials, Xi'an Jiaotong University,

出　　处：《无机材料学报》2001年第3期522-528,共7页Journal of Inorganic Materials

基　　金：国家自然科学基金!(59872026);教育部"跨世纪人才培养计划"!(96年度)

摘　　要：采用等离子喷涂ＣａＨＰＯ４和水热处理复合制备羟基磷灰石生物涂层，研究了羟基磷灰石涂层的结合强度和溶解性，用成骨细胞考察了生物相容性．结果表明：喷涂涂层由ＣａＨＰＯ４、β－Ｃａ２Ｐ２Ｏ７和α－Ｃａ３（ＰＯ４）２组成，其相比例、结晶性和形貌取决于喷涂电流和喷涂距离；喷涂涂层经过水热处理可转化为针状结晶的缺钙羟基磷灰石；这种羟基磷灰石涂层具有高的结合强度和稳定性，与成骨细胞的生物相容性良好．The hydroxyapatite coating was hydrothermally prepared from plasma sprayed CaHPO4 coating and its bonding strength and solubility were studied. The osteoblast culture test was also produced in order to examine the biocompatibility of the coating. The as-sprayed coating consists of CaHPO4, beta -Ca2P2O7 and alpha -Ca-3(PO4)(2), and the phase ratio, crystallity and morphology are dependent on spraying current and stand-off distance. The as-spayed coating can be converted to calcium-deficient hydroxyapatite coating with needle-like crystals by hydrothermal treatment. The hydrothermally synthesized hydroxyapatite coating having high bonding strength and stability, possesses good biocompatibility with the osteoblast.

关 键 词：羟基磷灰石 生物涂层 等离子喷涂 水热合成 细胞实验 生物材料 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]