有机和有机金属多酸化合物生物活性研究  

Bioactivity of Organic and Organometallic Substituted Polyoxometalates

作　　者：刘景福[1] 王晓红[1] 孙振刚[1] 李恒达[1] 

机构地区：[1]东北师范大学化学学院,长春130024

出　　处：《应用化学》2001年第5期357-359,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目! (39970 842 )

摘　　要：报道一系列有机锡 ,有机钛 ,有机锆和有机膦取代多酸化合物对两种人体肿瘤细胞 SSMC-772 1和Hela的抗肿瘤活性 .其中有机钛多酸化合物表现为高于其他具有相同多酸阴离子的化合物的抗肿瘤活性 .发现化合物具有很高的体内抗肿瘤活性和较低的毒性 ,并发现化合物的抗肿瘤活性与化合物的氧化还原能力呈顺变关系 .A number of organotin, cyclopentadienyltitanium, cyclopentadienylzirconium and organophosphoryl substituted polyoxometalates are reported in relation of their antitumor activity against SSMC-7721 and Hela human tumor cells. The cyclopentadienyltitanium polyoxometalates showed higher activity than other compounds with the same polyanions. CoW 11 CpTi was found to have higher antitumor activity and low toxicity as showed in vivo tests. It is also observed that the order of the antitumor activity of complexes is in relation with the order of the redox behavior of the polyanions.

关 键 词：有机金属 多酸化合物 抗肿瘤活性 抗肿瘤药剂 药理 

分 类 号：R979.1[医药卫生—药品] R965[医药卫生—药学]