善得定对预防大鼠腹部手术后肠粘连的研究  

Prevention of postoperative abdominal adhesions with sandostatin in rats

作　　者：裴海平[1] 晏仲舒[1] 伍韶斌[1] 

机构地区：[1]中南大学湘雅医院普外科,湖南长沙410008

出　　处：《中国普通外科杂志》2001年第3期231-233,共3页China Journal of General Surgery

摘　　要：目的　评价腹腔注射善得定对大鼠腹部手术后肠粘连的预防作用。方法　将 5 0只SD大鼠随机分为 5组 :Ⅰ组 ,对照组 ;Ⅱ组 ,腹腔内注射善得定 2 0 μg kg ;Ⅲ组 ,腹腔内注射善得定 40 μg kg ;Ⅳ组 ,腹腔内注射善得定 6 0 μg kg ;Ⅴ组 ,腹腔内注射透明质酸钠。各组动物均于术后 14d处死 ,肉眼评价粘连程度 ,并取粘连的肠段测羟脯氨酸 (OHP)。结果　Ⅱ ,Ⅲ ,Ⅳ ,Ⅴ组之粘连程度明显低于Ⅰ组 (P <0 .0 5 ) ;Ⅱ ,Ⅲ ,Ⅳ组粘连肠段的OHP明显低于Ⅰ组和Ⅴ组(P <0 .0 5 ) ;Ⅱ ,Ⅲ ,Ⅳ组间粘连程度及粘连肠段的OHP无明显差异 (P >0 .0 5 )。Objective To assess the efficacy of sandostatin in preventing postoperative adhesions in rats. Methods Fifty SD rats were randomly divided into five groups: Group 1, Control group; group 2, sandostatin 20μg/kg intraperitoneal injection (IP); group 3, sandostastin 40μg/kg IP; group 4, sandostatin 60μg/kg IP; group 5, hyaluronate sodium(HA) IP. All animal were killed on the 14th postoperative day. After adhesions were graded according to their severity, adhesive ileal segments were resected for hydroxyproline(OHP) determination. Results The severity of adhesions in group 2.3.4 and 5 were significantly milder than that in group 1.(P<0.05). The OHP levels of adhensive intestine in group 2.3 and 4 were significantly lower than that in group 1 and 5 (P<0.05).The severity of adhesions and OHP levels in group 2.3 and 4 had no significant difference (P>0.05). Conclusions Intraperitoneal administration of sandostatin intraoperatively might have some efficacy in preventing adhensions of intestine.

关 键 词：肠粘连/预防和控制 善得定/治疗应用 腹部/外科学 手术后并发症 大鼠 

分 类 号：R656[医药卫生—外科学]