不同剂量大枣对D-半乳糖衰老小鼠SOD活性和MDA含量影响的实验研究  

Effect of Dazao on SOD activity and MDA content in the brain of D-galactose-induced senile mice

作　　者：杨新宇[1] 王建光[1] 李新成 张涛 白书阁 

机构地区：[1]佳木斯大学基础医学院生化教研室 [2]佳木斯中药厂

出　　处：《黑龙江医药科学》2001年第2期13-14,共2页Heilongjiang Medicine and Pharmacy

摘　　要：本实验以昆明种小鼠为研究对象，颈背部注射 Ｄ－ｇａｌ建立衰老模型，同时以大枣作为抗衰老实验药物灌服，测定了脑组织内超氧化物歧化酶（ＳＯＤ）活性、丙二醛（ＭＤＡ）含量．实验结果表明：不同剂量大枣均可提高小鼠脑组织 ＳＯＤ活性，并能降低脑组织 ＭＤＡ含量．说明不同剂量大枣均可提高小鼠脑组织ＳＯＤ活性，并能降低脑组织ＭＤＡ含量，大枣具有一定的抗衰老作用．In this experiment D-gal was injected into the mice's scruff of the neck subcntaneous tissne to creat a model of aging. At the same time the mice were filled with different doses of the uazao. After six weeks the effect of Dazao on SOD activity and the content of MDA was observed in the brain of D-galactose-induced senile mice. The activities of SOD in the brain were increased after giving different doses of extracts of Dazao, while the content of MDA in the brain was decreased. The antioxidant action of the high dose of Dazao. had a better effect. Different doses of Dazao extracts had antiaging effect.

关 键 词：SOD MDA 衰老小鼠 D-半乳糖 大枣 

分 类 号：R339.38[医药卫生—人体生理学]