高效液相色谱法测定恶丙嗪片的含量  

High performance liquid chromatographic determination of oxaprozin tablets

作　　者：郭宏[1] 高金波[1] 邱树勇 

机构地区：[1]佳木斯大学佳木斯,154002

出　　处：《黑龙江医药科学》2001年第2期16-16,共1页Heilongjiang Medicine and Pharmacy

摘　　要：目的：建立高效液相色谱法测定恶丙嗪片含量的方法．方法：色谱柱： ＤｉａｍｏｎｓｉｌＣ１８（２００ × ４．６ｍｍ， ５μｍ），流动相：甲醇水（８０： ２０），检测波长：２８５ｎｍ．结果：恶丙嗪线性范围５～４５μｇ／ｍｌ，回归方程为Ｃ＝０． ０６２４Ａ＋４５． ２２９ｒ＝０．９９９９，回收率为９９．８６％，日内精密度为ＲＳＤ＝０．９２％，日间精密度为ＲＳＤ＝１．６４％结论：方法准确、快速、简便．Objective: To study high performance liquid chromatography for the determination of oxaperozin tablets. Methods: Diamonsil C18(200 × 4.6nun, 5μm) column was used, mobile phase was MeOH-water (80:20), and detection wavelength was 285nm. Results: Over the concentration range of 5-45μg/ml, the linear regressin equation was C=0.0624A+45.229, r=0.9999. The average recovery was 99.86%, The within-day RSD=0.92%. Conclusions: The method is found to be accurate.

关 键 词：高效液相色谱法 恶丙嗪 含量 测定 

分 类 号：R927.2[医药卫生—药学]