半夏泻心颗粒剂改善胃动力的实验研究  

Experimental studies on improvement of gastric dynamic with granulater of Banxia xie xin

作　　者：高景泰[1] 沃艳 潘洋[1] 郑晓光[1] 王伟明[1] 战玉晶[1] 柳阳明 

机构地区：[1]黑龙江省中医研究院 [2]黑龙江省医药设计院 [3]哈尔滨制药总厂

出　　处：《黑龙江医药科学》2001年第2期17-18,共2页Heilongjiang Medicine and Pharmacy

摘　　要：本实验以ｗｉｓｔａｒ大鼠和昆明种小白鼠为研究对象，观察“半夏泻心颗粒剂”对大鼠体表胃肌电ＡＰ值、 ＦＰ值以及大、小鼠胃排空率指标，用“酚红法”、“体表胃肌电法”实验并同时做了自身用药前后对比，生理盐水对照和吗丁啉治疗对照．结果“半夏泻心颗粒剂”１．８ｇ／ｋｇ，０．９ｇ／ｋｇ使大鼠体表胃肌电ＡＰ值提高３７．５％、８２．４％（Ｐ＜０．０１），ＦＰ值提高４３．３％、１８．３％．胃排空率，大鼠提高５４．２％（Ｐ＜０．０５），５４．９％（Ｐ＜０．０５）小鼠胃排空影响明显，与生理盐水组比较，９ｇ／ｋｇ组Ｐ＜０．０５，６ｇ／ｋｇ组Ｐ＜０．０１，３ｇ／ｋｇ组Ｐ＜０．０１，分别与吗丁啉组接近，结果提示“半夏泻心颗粒剂”有改善大鼠体表胃肌电，提高大、小鼠胃排空的作用．In order to determine the effect of 'granulater of Ban xia xie xin (BXXX)' on gastric dynamic, rat gastro- electrogastrography and rats and mouses red phenal gastrexcretion test were done after administration. The result showed that The gastro-myoelectric AP value of rat body surface was increased by 37.5% or 82.4%(P<0.01) with 1.8g/kg or 0.9g/kg of granulater of BXXX, and FP by 43.3% or 18.3%, respectively. Red phenal gastrexcretion test showed that gastrexcretion rate was increased by 54.2%(P<0.05) and by 59.4%(P<0.05) in rats, but in mice, the effective gastrexcretion was observed (P<0.01), indicating that 'granulated of BXXX' had effects of gastro-myoelectric improvement of rat body surface and increase in rat and mouse red phenal gastrexcretion rate.

关 键 词：半夏泻心颗粒剂 体表胃肌电 胃排试验 中药 

分 类 号：R283.626[医药卫生—中药学]