甲基麻黄素羧酸酯类的合成  

Synthesis of α-[1-(dimethylamino)ethyl]benzyl esters

作　　者：程石泉[1] 乌力吉木仁[1] 李慧超[1] 王菊平[1] 申静[1] 

机构地区：[1]内蒙古医学院药学系

出　　处：《化学试剂》1991年第1期26-28,共3页Chemical Reagents

摘　　要：合成了九种甲基麻黄素羧酸酯类化合物。以甲基麻黄素为母体,无水苯为溶剂,回流,在反应物的分子中引入萘普生酰基、烟酰基、呋喃甲酰基、氯乙酰基、溴乙酰基等具有某些生物活性的酰基。所有的产物都作了结构分析和元素分析,证明其中有六种化合物是首次合成的。Nine α-[1-(dimethylamino)ethyl benzyl]-esters[Ⅰ～Ⅸ]were prepared by reaction of[(+)-6′-methoxy-2′-methyl(2-naphthalene)]acetyl chlo-ride,nicotinyl chloride,p-nitrobenzoyl chloride,chloroacetyl chloride,3-furoyl chloride,bro-moacetyl chloride,p-methoxybenzoyl chloride,benzoyl chloride and acetyl chloride with α-[1-(dimethylamino)ethyl]benzyl alcohol in drybenzene on a water bath for one to three hours.The structures of all the compounds synthe-sized were confirmed by elemental analysis,ultra-violet and infrared spectra.

关 键 词：甲基麻黄素 羧酸酯类 酯类化合物 

分 类 号：O629.3[理学—有机化学]