持续、低剂量金霉素对肉仔鸡免疫机能的抑制作用研究  

Immunosuppressant Effect of Long Term and Subtherapeutic Chlortetracycline in Broiler

作　　者：佟建明[1] 张日俊[2] 萨仁娜[1] 潘淑瑗 黄燕[3] 

机构地区：[1]中国农业科学院畜牧研究所 [2]中国农业大学动物科技学院 [3]中国农业大学基础科技学院,北京100094

出　　处：《中国农业科学》2001年第2期200-204,共5页Scientia Agricultura Sinica

基　　金：国家科技攻关项目(99-009-02-01)

摘　　要：２７０只 Ａｂｏｒｅ Ａｃｒｅ商品代肉用公鸡随机分成 ３组，金霉素在饲料中添加水平分别为 ０．５０和 １５０ｍｇ／ｋｇ，研究饲用金霉素对肉仔鸡法氏囊、脾脏和胸腺等免疫器官发育、以及免疫反应的影响。结果表明，５０ｍｇ／ｋｇ的金霉素对肉仔鸡脾脏和 ２１日龄的胸腺无明显抑制作用，对 Ｔ、Ｂ淋巴细胞转化率也无明显抑制作用；１５０ｍｇ／ｋｇ的金霉素对肉仔鸡的胸腺和脾脏发育具有显著的抑制作用（Ｐ＜０．０５），而且显著促进法氏囊的萎缩（Ｐ＜０．０５）。金霉素对Ｔ淋巴细胞转化率有明显的直接抑制作用；５０ｍｇ／ｋｇ和１５０ｍｇ／ｋｇ的金霉素对ＢＳＡ特异性抗体的产生均有显著的抑制作用（Ｐ＜０．０１）。研究结果表明，持续、低剂量的金霉素对肉仔鸡免疫器官发育和免疫应答具有显著的抑制作用，抑制作用随剂量增加而加强。１５０ｍｇ／ｋｇ的金霉素对肉仔鸡具有显著促生长作用。Experiments were conducted with 270 Abore Acre male broilers to study the influence of dietary chlortetracycline(CTC) on the bursal, thymus and spleen weight index and T,B cell proliferation and antibody responses of broilers. Results show that 50mg/kg CTC had no significant inhibitory effect on thymus and spleen weight index, and T,B cell proliferation of broilers at 21 day old. 150mg/kg CTC had significant inhibitory effect on bursal , thymus and spleen, and T,B cell proliferation(P<0. 05). Dietary CTC had a direct inhibitory effect on lymphocyte proliferation in vitro . 50mg/kg and 150mg/kg CTC have significant inhibitory effect on the antibody responses to BSA(P<0. 01). Results demonstrated that sub-therapeutic and long term CTC had significant inhibitory effects on immune organs and antibody response. The immunosuppressant effect became higher when the level of CTC increased. 150mg/kg CTC increased the growth rate of broilers significantly.

关 键 词：免疫抑制 金霉素 肉仔鸡 饲用抗生素 

分 类 号：S816.73[农业科学—饲料科学] S831.5[农业科学—畜牧学]