新药“宁静液”的药效、毒理实验研究  

Study on Pharmacology and Toxicology of the New Drug “Ningjingye”

作　　者：张静[1] 徐鸽[1] 孙琦 

机构地区：[1]江苏石油化工学院化学工程系,江苏常州213016 [2]威康特塑料公司,江苏常州213015

出　　处：《江苏石油化工学院学报》2001年第1期21-23,共3页Journal of Jiangsu Institute of Petrochemical Technology

基　　金：常州市科学技术委员会基金!资助 ([2 0 0 0 ]81)

摘　　要：研究从阔叶树木中提取、分离、配制的木质素类中药宁静液 ,对急性软组织挫伤及皮肤破损方面进行了药效试验 ,为临床安全用药提供科学依据。对小鼠进行口服 ,对豚鼠进行完整和破损皮肤药物接触后可能产生的毒性反应 ,过敏反应及刺激反应。宁静液对小鼠口服给药的最大耐受量为 80mL/kg。皮肤受药后在激发 2 4小时、 48小时、 72小时皮肤未见一例出红斑 ,判定宁静液无过敏反应 ,经皮肤刺激反应评分标准判定平均分值为 0 16。The efficacy of Ningjingye on acute injures of soft tissue is studied in order to provide the scientific basis for clinic safety. Ningjingye is a Chinese medicine abstracted, separated and compounded from broadleaf trees. In studying the toxicity reaction,the medicine was tried on mice.To observe allergy and stimulation reactions,the medicine was applied to the skin and bruises of guinea pigs. The maximum oral dose for mice is 80mL/kg.After 24h,48h,72h with Ningjingye, the erythema was not found in all, that is, there was no allergy reaction with Ningjingye. The average value is 0 16 by evaluation standard of stimulation reaction, and it shows no stimulation from Ningjingye.

关 键 词：宁静液 中药 急性软组织挫伤 药效 毒理 木质素类高分子化合物 

分 类 号：R285[医药卫生—中药学] R286[医药卫生—中医学]