丙型肝炎患者外周血B细胞和T细胞及其亚群的研究  

Study on B lymphocyte,T lymphocyte and its subgroups in peripheral blood in patients with hepatitis C

作　　者：刘洪月[1] 何浩明[2] 田小平[2] 袁兵[3] 徐凤英[2] 庄惠芹[2] 

机构地区：[1]江苏省连云港市第一人民医院消化内科,222002 [2]江苏省连云港市第一人民医院临床免疫研究室,222002 [3]镇江医学院检验系,实习生江苏2222002

出　　处：《淮海医药》2001年第3期186-187,共2页Journal of Huaihai Medicine

摘　　要：目的　了解丙型肝炎患者外周血 B细胞和 T淋巴细胞及其亚群的变化。方法　应用单克隆技术测定 38例丙型肝炎患者外周血 B细胞和 T淋巴细胞亚群的水平并以 35名健康人作对照。结果　丙型肝炎患者外周血 B细胞数显著地高于正常人 (P<0 .0 0 1)、CD3、CD4、CD4/ CD8显著低于正常人 (P<0 .0 1,P<0 .0 0 1)。结论　丙型肝炎患者为一种自身免疫调节异常的疾病。Objective To study the changes of B lymphocyte,T lymphocyte,and its subgroups in peripheral blood in patients with hepatitis C.Methods B lymphocyte,T lymphocyte and its subgroups in peripheral blood in 38 patients with hepatitis C and 35 normal controls were detected with monoclonal technigue.Results The level of B lymphocyte were significanty higher than those in normal people( P <0.001).But CD 3、CD 4 and the ratio of CD 4/CD 8 were obviously lower( P <0.01, P <0.001).Conclusion Hepatitis C is a kind of selfi-mmunity disease with abnormal immunoregulation.

关 键 词：丙型肝炎 B细胞 T淋巴细胞亚群 

分 类 号：R512.630.3[医药卫生—内科学]