O157感染死亡病例的流行病学调查报告  

REPORT OF EPIDEMIOLOGICAL INVESTIGATION ON DEATH CASE CAUSED BY E.COLI O157 INFECTION WHICH WAS FIRST DISCOVERED IN HEBEI PROVINCE.

作　　者：陈素良 郭逸秀 李胜奎[2] 张亚利 董会敏[2] 李桂银 韩秀兰[2] 董辉 徐宝宏[2] 宫喜禄 刘新立[2] 郝瑞旗 马学志 侯通[2] 朱会宾 景怀琦[4] 程伯鲲[4] 

机构地区：[1]河北省卫生防疫站,保定071000 [2]石家庄市卫生防疫站 [3]赞皇县卫生防疫站 [4]中国预防医学科学院微生物学流行病学研究所

出　　处：《现代预防医学》2001年第2期169-170,174,共3页Modern Preventive Medicine

摘　　要：目的 :证实肾衰死亡病例的死因 ,了解 O15 7:H 7疫源地的人群和动物感染状况。方法 :对肾衰病人、同村居民及其同事进行调查 ,用常规方法分离腹泻病人、密切接触者和动物粪便中 O15 7:H7。用蛋白印迹实验检测抗 O15 7:H 7L PSIg G和 Ig M抗体。结果 :从肾衰病人、同村腹泻病人及密切接触者的血清中检出 O15 7:H 7L PS Ig G和 Ig M抗体 ;从病人的家庭密切接触者 16份粪便中检到 1株 O15 7大肠杆菌 ;2 2例腹泻患者粪便中检出 1株 ,75份猪粪中检出 3株 ,4份牛粪中检出 1株 O15 7。结论 :肾衰死亡病例为 O15 7:H7感染所致 。Objective:To identificate the cause of death of a kidney failure patient and get the E.coli O157 infection state among different population and animals in epidemic focus.Methods:The kidney failure patient,residents lived in the patients same villiage and his co workers were investigated.Stools from diarrhea patients,close contactors and animals were tested by routine isolation of E.coli O157:H7 method.IgG and IgM for E.coli O157:H7 LPS were tested by western blot method.Results:IgG and IgM for LPS were positive in serum of the patient died with kidney failure,his colleagues,diarrhea cases and familial close contactors.E.coli O157 in stools were tested out from 1(6 25%) of 16 familial close contactors,1(4 5%) of 22 diarrhea cases,3(4 0%) of 75 pigs and 1(25 0%) of 4 cattles.Conclusion:One death case caused by E.coli O157:H7 infection was first discovered in Hebei province.Infection rate of E.coli O157:H7 among pupulation and animals were higher in epidemic focus.

关 键 词：O157:H7 急性肾功能衰竭 动物粪便 腹泻 流行病学 

分 类 号：R516.01[医药卫生—内科学]