实验性不同类型大鼠臂丛根性损伤后脊髓运动神经元存活情况观察  

Survival of spinal motoneurons after various types of brachial plexus root injuries: an experimental study

作　　者：张立群[1] 朱维钦[1] 林建华[1] 

机构地区：[1]福建医科大学附属第一医院骨科,福州市350005

出　　处：《中华手外科杂志》2001年第2期116-118,共3页Chinese Journal of Hand Surgery

基　　金：福建省科委科研基金资助项目!(98 Z 1 66)

摘　　要：目的　研究臂丛神经根性切断伤与根性撕脱伤后脊髓前角运动神经元的存活情况。方法　对 76只健康成年SD大鼠 ,按手术先后顺序分成臂丛神经根性切断伤组和根性撕脱伤组 ,两组按术后 9个不同的时间组取材 ,每组 4只大鼠 ,共 72只大鼠。另外 4只为正常对照组。取出脊髓标本后 ,观察颈髓前角运动神经元数目的变化。结果　臂丛神经根性切断伤后 ,各时间组的脊髓前角运动神经元数目和术前无明显变化 ;而根性撕脱伤组于术后 1周其神经元数目开始减少 ,术后 2周时神经元数目比正常对照组减少 3 0 % ,术后 6周时减少 70 %。撕脱伤组与切断伤组相比 ,损伤 1周后 ,各时间组的差异均有显著性意义 ( χ2 =3 .92 2～ 17.2 1,P <0 .0 1)。结论　臂丛神经根性切断伤其脊髓运动神经元和术前比无明显变化 ,而臂丛神经根性撕脱伤后其脊髓运动神经元有死亡 ,死亡速度快 ,死亡程度高。Objective To investigation survival of spinal motoneurons after brachial plexus root rupture or avulsion injury. Methods 72 adult healthy SD rats were randomly divided into two groups, root rupture and root avulsion. Spinal cord sample was harvested at 9 different postoperative intervals, with 4 rats each. Another 4 rats served as control. The number of the motoneurons in the cervical spinal cord anterior horn was calculated.Results There was no significant change in the number of spinal motoneurons in the root rupture group. In the root avulsion group, the number of spinal motoneurons began to decrease 1 week postoperatively, and was 30 % and 70 % less than that of the control group 2 weeks and 6 weeks after the operation respectively. Compared to that in root rupture group, significant difference was seen at different intervals in root avulsion group 1 week after the operation.Conclusions Root rupture of the brachial plexus did not cause remarkable change of the spinal motoneurons. Root avulsion, however, resulted in death of spinal motoneurons with rapid speed and severe extent.

关 键 词：臂丛 传出神经元 脊髓 细胞死亡 细胞存活 

分 类 号：R651.3[医药卫生—外科学]