博利康尼片中硫酸特布他林含量的HPLC测定  

Determination of Terbutaline Sulphate in Bricanyl Tablets by HPLC

作　　者：曹玲[1] 周帼雄[1] 

机构地区：[1]江苏省药品检验所,江苏南京210008

出　　处：《中国医药工业杂志》2001年第6期262-263,共2页Chinese Journal of Pharmaceuticals

摘　　要：建立了博利康尼片中硫酸特布他林含量的 HPL C测定法。色谱柱为 Shim - pack VP- ODS(15 0× 4.7m m ,5μm ) ,0 .0 0 5 mol/ L辛烷磺酸钠 (用醋酸调节 p H值至 3.4) -乙腈 (77∶ 2 3)为流动相 ,检测波长为 2 80 nm。平均回收率为 99.7% ,RSD为 0 .81% ;方法的线性范围为 1× 10 - 3～ 1mg/ m l,r=0 .9999。日内和日间测定的 RSD分别为0 .2 6 %、0 .88%An accurate method for the determination of terbutaline sulphate in the Bricanyl tablets was established, using Shim pack VP ODS column (150×4.7 mm,5 μm) with the mobile phase of 0.005 mol/L sodium 1 octanesulfonate solution (pH adjusted to 3.4 with acetic acid) acetonitrile (77∶23), at the detection wavelength of 280 nm. The average recovery was 99.7%, and the RSD was 0.81%. It had a good linearity between the range of 1×10 -3 ～1 mg/ml( r =0.9999). The RSD of intra and inter day were 0.26% and 0.88%, respectively.

关 键 词：磙酸特布他林 HPLC 测定 博利康尼片 含量 哮喘 支气管炎 

分 类 号：R927.2[医药卫生—药学] R974