肉苁蓉总苷对兔失血性休克/再灌注的影响  

PROTECTIVE EFFECTS OF GLYCOSIDES OF CISTANCHE ON HEMORRHAGIC SHOCK/REPERFUSION INJURY IN RABBITS

作　　者：梁明华[1] 孙沛毅[1] 吴一丁[1] 

机构地区：[1]扬州大学医学院基础部,江苏扬州225001

出　　处：《扬州大学学报（自然科学版）》2001年第2期35-36,49,共3页Journal of Yangzhou University：Natural Science Edition

摘　　要：研究肉苁蓉总苷 ( GC)对兔失血性休克 /再灌注 ( S/ R)损伤的保护作用及其机制 .用家兔 S/ R模型 ,观察血浆中丙二醛 ( MDA)含量、超氧化物歧化酶 ( SOD)活性和血栓素 A2 ( TXA2 )、前列环素 ( PGI2 )代谢产物的浓度以及 GC对上述指标的影响 .结果表明 :与 S/ R组比较 ,GC治疗组可使血浆中 MDA和TXB2 ( TXA2 的代谢产物 )明显降低 ,SOD和 6酮 PGF1α( PGI2 的代谢产物 )明显升高 .说明 GC对 S/To study protective effects of glycosides of cistanche on hemorrhagic shock/reperfusion injury (S/R). Changes of several parameters and effects of GC on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model, parameters of which included MDA, SOD, TXB 2 and 6ketoPGF 1α . Results: MDA and TXB 2 decreased significantly ( P <0.01), SOD and 6ketoPGF 1α increased significantly ( P <0.05) in GC group compared with S/R group. GC has protective effects for rabbits on hemorrhagic shock/reperfusion injury.

关 键 词：肉苁蓉总苷 失血性休克 缺血 再灌注 损伤 超氧化物歧化酶 

分 类 号：R441.9[医药卫生—诊断学]