血脂康对老年陈旧性心肌梗死患者氧化修饰低密度脂蛋白及血管内皮功能的影响  

Effects of Xuezhikang on Functions of Vascular Endothelial Cells and the Serum Level of OX-LDL in the Elderly with OMI

作　　者：陈建国[1] 徐伯平[1] 程蕴琳[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2001年第4期322-324,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的 :探讨血脂康对老年陈旧性心肌梗死 (OMI)患者血氧化修饰低密度脂蛋白 (OX LDL)水平和血管内皮功能的影响。方法 :老年OMI患者及健康老年人 (对照组 )各 32例 ,空腹 12h后查血清脂质总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、OX LDL、内皮素 (ET 1)和一氧化氮 (NO)水平 ,老年OMI患者给予血脂康 0 .6 g ,每日 2次 ,8周后复查OX LDL、ET 1和NO水平。 结果 :与对照组相比 ,老年OMI患者治疗前血清中脂质水平差异无显著性 ,血清中OX LDL和ET 1水平升高 [(1171.1± 5 0 4.2 )对 (4 14.9± 10 7.8) μg/L和 (10 4.48± 32 .30 )对 (6 4.40±18.0 4) pg/ml) ],NO水平低于对照组 [(4 4.78± 15 .40 )对 (77.78± 2 5 .79) μmol/L],差异有显著性 (P <0 .0 1) ;经血脂康治疗后 ,老年OMI患者OX LDL和ET 1水平较治疗前下降 [(874.2± 30 5 .0 )对 (1171.1± 5 0 4.2 ) μg/L和 (89.15± 2 0 .78)对(10 4.48± 32 .30 ) pg/ml],NO水平升高 [(5 6 .6 0± 13.6 2 )对 (4 4.78± 15 .40 ) μmol/L],差异有显著性 (P <0 .0 5 )。 结论 :血脂康具有抑制脂质过氧化反应 ,减低OX LDL水平 ,保护老年OMI患者血管内皮功能的作用。Objective:To evaluate the effects of Xuezhikang on the functions of vascular endothelial cells and the serum level of oxidatively modified low density lipoprotein (OX-LDL) in the elderly patients with old myocardial infarction (OMI). Methods:The levels of the serum total cholesterol (TC), triglycerid (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), endothelin (ET-1) and nitrous oxide (NO) were determined in 32 elderly patients with OMI (OMI group) and 32 elderly healthy controls (control group). All serum parameters were determined once again in OMI group after 8 weeks of treatment with Xuezhikang (0.6 g bid PO×8 weeks). Results:As compared with the control group, the levels of the serum lipid parameters had no significant difference (P>0.05), but the serum OX-LDL and ET-1 were higher [(1 171.1±504.2) vs (414.9±107 8) μg/L, (104.48±32.30) vs (64.40±18.04) pg/ml, P<0.01, respectively] and NO was lower [(44.78±15.40) vs (77.78±25.79) μmol/L, P<0.01, respectively] in the OMI group before treatment with Xuezhikang. After 8 weeks of treatment with Xuzhikang the serum OX-LDL and ET-1 of the OMI group was lower [(87.42±30.50) vs (117.11±50.42) μg/L, (89.15±20.78) vs (104.48±32.30) pg/ml, P<0.05 respectively] than the previous and the serum NO was significantly increased [(56.60±13.62) vs (44.78±15.40) μmol/L, P<0 05, repectively]. Conclusion:Xuezhikang has a role of inhibiting the lipid peroxidation and protects the functions of vascular endothelial cells in the elderly patients with OMI.

关 键 词：血脂康 心肌梗死 氧化修饰低密度脂蛋白 老年人 血管内皮功能 

分 类 号：R542.22[医药卫生—心血管疾病] R972.6[医药卫生—内科学]