氟桂利嗪口服液的人体相对生物利用度研究  

Relative Bioavailability of Flunarizine Oral Solution

作　　者：侯淑贤[1] 吴立[1] 李培坚[2] 周正航[3] 邵春丽[1] 代宗顺[2] 

机构地区：[1]华中科技大学同济医学院基础医学院药理学教研室,武汉430030 [2]华中科技大学同济医学院实验动物学部,武汉430030 [3]华中科技大学同济医学院基础医学院临床药理学教研室,武汉430030

出　　处：《同济医科大学学报》2001年第2期137-138,141,共3页Acta Universitatis Medicinae Tongji

摘　　要：用高效液相色谱 ( HPL C)法测定氟桂利嗪血药浓度。Spherisorb- C18为固定相 ,流动相为甲醇∶醋酸缓冲液( 8∶ 2 ,p H5 .5 ) ,UV2 10 nm检测 ,线性浓度范围 5～ 10 m g/ ml,方法回收率 80 .4 %～ 83 .2 %。应用该法研究了氟桂利嗪口服液的人体相对生物利用度为 ( 10 9.4± 6.8) % ,结果表明 ,两种制剂的 AU C、Tmax、Cmax之间无显著性差异。High performance liquid chromatography was used to determine the blood concentration of flunarizine with Spherisorb C18 as the stationary phase and methyl alcohol∶HAC buffer 8∶2 (pH 5 5) as the mobile phase The detection wave length was 210 nm The linear rang was 10 to 100 ng/ml The recovery rate was (81 7±1 4) % There was no significant difference between AUC,Tmax,Cmax of two products, respectively The relative bioavailability of flunarizine oral solution was (109 4±6 8) % The bioavailability of flunarizine oral solution was bioequivalent to flunarizine capsules

关 键 词：氟桂利嗪口服液 生物利用度 高效液相色谱法 

分 类 号：R972[医药卫生—药品] R969.1[医药卫生—药学]