老年冠心病患者纤溶酶原激活抑制剂的变化  

Plasminogen activator inhibitor associated with coronary artery disease in elderly patients

作　　者：傅研[1] 王旭东[1] 翟艳苓[1] 朱宇清[1] 王瑾[1] 赵相印[1] 

机构地区：[1]首都医科大学附属北京同仁医院急诊科,北京市100730

出　　处：《中华老年医学杂志》2001年第3期189-190,共2页Chinese Journal of Geriatrics

摘　　要：目的　探讨老年人冠心病与纤溶酶原激活抑制剂 (PAI)的关系。　方法　测定了 93例老年冠心病患者的PAI和组织型纤溶酶原激活剂 (t PA)活性、胆固醇和甘油三酯的血浆水平 ,并与健康对照组比较。　结果　冠心病组的PAI活性〔(810± 36 0 )AU/L〕明显高于健康对照组〔(6 40± 30 0 )AU/L ,P <0 0 1〕 ;冠心病组的t PA活性〔(390± 140 )IU/L〕明显低于对照组的水平〔(4 90± 2 40 )IU/L ,P <0 0 5〕。　结论　老年人PAI活性的增高和t PA活性的降低可能参与了冠心病的发病机制。Objective To investigate the relationship between plasminogen activator inhibitor(PAI) activity and coronary artery disease(CAD) in elderly patients. Methods Plasma samples from 93 patients with CAD were analyzed for the PAI activity, plasminogen activator(t-PA) activity, serum levels of cholesterol and triglyceride. The values of these parameters were compared between the CAD and the control groups. Results Higher plasma PAI activity 〔(810±360) AU/L vs. (640±300) AU/L,P<0.01〕 and lower t-PA activity 〔(390±140)IU/L vs. (490±240) IU/L,P<0.05〕 were found in CAD patients than in control group. Conclusions The increase of PAI activity and decrease of t-PA activity in elderly patients might be involved in the pathogenesis of CAD.

关 键 词：冠心病 纤溶酶原激活抑制剂 老年人 T-PA 胆固醇 甘油三酯 

分 类 号：R541.4[医药卫生—心血管疾病]