血小板、红细胞多不饱和脂肪酸的平衡及低密度脂蛋白的作用  

Balance of Polyunsaturated Fatty Acids on Platelet and Erythrocyte Membrane and Effect of Low Density Lipoprotein

作　　者：陈松鹤[1] 应赛亚[1] 李旭日[1] 王建中[2] 

机构地区：[1]上海医科大学附属中山医院内科 [2]上海东海制药厂

出　　处：《基础医学与临床》1991年第5期50-53,共4页Basic and Clinical Medicine

摘　　要：低密度脂蛋白引起血小板、红细胞膜上二十碳四烯酸,二十碳五烯酸、二十二碳六烯酸成份改变,并与它们的功能改变相关。摄入富含二十碳五烯酸,二十二碳六烯酸的鱼油脂肪后,低密度脂蛋白的上述作用减弱。影响n-3型和n-6型多不饱和脂肪酸的平衡可能是低密度脂蛋白对血小板、红细胞的作用机理之一。Activation of platelet and alteration of erythrocyte deformability and fluidity by low density lipoprotein(LDL) were accompanied by a substantial fall in arachidonic acid (AA, C20:4 n-6 ) and a significant rise in eicosapentaenoic acid (EPA, C20:5 n-3)and docosahexaenoic acid ( DHA, C22:6 n-3 ) . LDL showed little effect on platelet and erythrocyte from the volunteers after dietary supplementation with EPA and DHA rich fish oil. The mechanism of action of LDL on platlet and erythrocyte may involve the balance of n-3 and n-6 polyunsalurated fatty acid on platelet and erythrocyt6 membrane.

关 键 词：低密度脂蛋白 血小板 红细胞 

分 类 号：R331.143[医药卫生—人体生理学]