APP转基因小鼠脑内单胺类递质的变化  

The Changes of Monoamine Transmitter in Mutant Amyloid Precursor Protein Transgenic Mouse Brain

作　　者：秦川[1] 常洋[1] 张文明[1] 朱华[1] 张均田[2] 屈志炜[2] 冯征[2] 

机构地区：[1]中国医学科学院中国协和医科大学实验动物研究所,北京100021 [2]中国医学科学院中国协和医科大学药物研究所,北京100021

出　　处：《上海实验动物科学》2001年第2期79-81,共3页Shanghai Laboratory Animal Science

基　　金：国家科技部基金项目(特别资助)

摘　　要：用 HPL C-ECD法对 APP695 ,75 1 V71 7I转基因模型小鼠大脑皮层神经递质进行检测 ,结果显示 APP75 1转基因鼠大脑皮层中的 5 -HIAA含量与对照组比较有显著性差异。APP695转基因鼠大脑皮层中 DA和 5 -HT平均含量分别比对照鼠升高 3 8.9%和 45 .8%。提示 Aβ的形成可能影响了多巴胺系统和 5 -羟色胺系统。Alzheimer's disease(AD) is a progressive neurodegenerative disease. It is known that AD is associated with some neuotransmitters disorder. We examine the monoamine transmitter in neuons of forebrain by HPLC-ECD method. The content of the 5-HIAA in APP amyloid precursor protein 751 trangenic mice show significant difference compared with that of the control group. The content of the DA and 5-HT in APP695 transgenic mice increased 38.9% and 45.8% respectively compared with control group. It suggested that the DA and 5-HT system may be affected respectively by Aβ.

关 键 词：阿尔茨海默病 APP转基因小鼠 神经递质 单胺类递质 

分 类 号：Q-332[生物学]