猪外周血淋巴细胞与心肌细胞β受体密度的相关性及其意义  

β-AR density relativity of porcine myocardial tissue and circulating lymphocytes and its significance

作　　者：黄子通[1] 王彤[1] 邱嘉民[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院急诊科,广州510120

出　　处：《中华急诊医学杂志》2001年第2期87-89,共3页Chinese Journal of Emergency Medicine

摘　　要：目的　定量检测猪外周血淋巴细胞与心肌细胞膜上 β AR密度 ,研究其相关性并探讨其临床意义。方法　利用待屠宰的生猪 (7月龄 )共 48头 ,取少许左心室肌组织及外周血 ,用放射性同位素的方法测定其 β AR密度。 结果　外周血淋巴细胞与心肌细胞膜 β AR密度之间的散点图呈直线状分布 ;它们之间的相关系数为 :r =0 845 ,P <0 0 0 1;其直线回归方程为 :y =0 0 0 2 5 2 7X +0 72 6。结论　猪外周血淋巴细胞与心肌细胞膜上 β AR密度具有明显的正相关性 ,故对外周血淋巴细胞膜 β AR密度的检测可反映其心肌细胞膜上 β AR密度的变化。结果提示 :可用外周血淋巴细胞膜 β AR密度的检测来监测本身或药物所诱导的心肌细胞膜上 β AR密度的变化。Objective To study β AR density relativity between porcine myocardial tissue and circulating lymphocytes and clinical significance .Methods 48 porcines(seven months old),were taken a few of myocardial tissue and peripheral blood.Assay β AR density with radioactive isotope to study the relativity.Results Scatter plot of β AR density circulating lymphocytes and myocardial tissue showed linear Correlation(r=0 845,P<0 001 Y=0 002527X+0 726).Conclusion There was obvious correlation on β AR density in circulating lymphocytes and myocardial membrane of pigs.Determination of β AR density in circulating lymphocytes can reflect alteration of that in myocardial tissue.Therefore,we can use it to monitor and investigate self induced and drug induced β AR changes.

关 键 词：Β肾上腺素能受体 相关性 淋巴细胞 心肌细胞 密度 猪 

分 类 号：R605.974[医药卫生—急诊医学]