血清可溶性E-选择素与2型糖尿病及其并发症相关性研究  

The relativity study between serum soluble E-selectin and type 2 diabetes mellitus and its microangiopathy

作　　者：张静[1] 陈菲[2] 马波[3] 

机构地区：[1]中国医科大学第一临床学院内分泌科,110001 [2]中国医科大学生化教研室 [3]辽宁省人民医院普外科

出　　处：《辽宁医学杂志》2001年第3期124-126,共3页Medical Journal of Liaoning

摘　　要：目的　观察血清可溶性E 选择素在 2型糖尿病患者中的水平的变化 ,探讨E 选择素在糖尿病及其微血管并发症中的可能的作用机制。方法　应用酶联免疫吸附法 ,对 5 0例 2型糖尿病患者及 2 0名健康对照者进行了能够反映体内E 选择素表达水平的血清可溶性E 选择素水平的测定。结果　 (1)正常人血清可溶性E 选择素浓度为 41 7± 17 0ng/ml。与正常对照组比较 ,无大血管及微血管并发症的单纯糖尿病患者的血清可溶性E 选择素水平显著升高 (5 2 9± 2 3 0ng/ml,P <0 0 5 )。 (2 )合并糖尿病微血管病变的患者血清可溶性E 选择素浓度为6 7 3± 32 9ng/ml,高于单纯糖尿病患者 (P <0 0 5 )及正常对照 (P <0 0 1)。 (3)糖尿病患者血清E 选择素浓度与HbA1c水平呈正相关 (γ =0 31,P <0 0 1)。结论　血清可溶性E 选择素水平在 2型糖尿病及其微血管并发症中升高 ,并与代谢控制水平相关。E 选择素作为一种内皮细胞特异的粘附分子可能参与糖尿病及其微血管并发症的病理过程。Objective To observe the level of serum soluble E selectin (sE selectin) in type 2 diabetes mellitus patients,and discuss the possible action mechanism of E Selectin in diabetes mellitus and its microanginopathy Methods ELISA is used to determine the sE selectin level in 50type 2 diabetes mellitus patients and 20 healthy patients as controls Results (1)The sE selectin level in health non-diabetic controls showed to be 41 7±17 0 ng/ml Compared with the control group, there's a significant rise of sE-selectin level in simple DM patients without microangiopathy (52 9±23 0 ng/ml, P<0 05) (2)sE selectin level was significantly higher in DM patients with diabetic microangiopathy (67 3±32 9 ng/ml)than in simple DM patients(P<0 05) and controls(P<0 01) (3)The sE selectin level was positively related to HbA 1c level in DM patients(γ=0 31,P<0 01) Conclusions The serum sE-selectin level was higher in type 2 diabetes mellitus and its microangiopathy complications It's very likely that E selectin contributes to the onset of diabetes mellitus and it's microangivpathy complications as an adhesion molecule specific to endothelial cell

关 键 词：E-选择素 血清可溶性E-选择素 Ⅱ型糖尿病 糖尿病微血管病变 并发症 视网膜病变 

分 类 号：R587.1[医药卫生—内分泌]