快速定量C-反应蛋白对小儿上呼吸道感染的临床意义  

Clinical significance of rapid quantity of CRP in children with upper respiratory infection

作　　者：杨力群[1] 王明月[1] 葛明[1] 沈德炜[1] 张萍[1] 牟春笋[1] 孔春妍[1] 

机构地区：[1]山东省济南铁路中心医院,济南250001

出　　处：《华北煤炭医学院学报》2001年第4期399-400,共2页Journal of North China Coal Medical College

摘　　要：1目的　探讨快速定量 CRP测定对鉴别小儿上呼吸道感染 (上感 )的病因的意义。 2方法　将 2 63例上感患儿随机分为两组 ,观察组用 Quick-Read CRP分析仪测定 CRP和血象 ,CRP≥ 10 m g/ L给予抗生素治疗 ,CRP<10 mg/ L给予抗病毒治疗 ;对照组只查血象 ,WBC≥ 10× 10 9/ L者给予抗生素治疗 ,WBC<10× 10 9/ L者给予抗病毒治疗。观察各组 3 d后体温降至正常例数。 3结果　 3 d退热例数分别为 :观察组 12 2例 (76.3 % ) ,对照组 5 0例 (48.5 % ) ,P<0 .0 0 1。两组应用抗生素治疗病例 3 d退热例数分别为 :观察组 40例 (76.9% ) ,对照组 2 1例 (43 .7% ) ,P<0 .0 1。两组应用抗病毒治疗 3 d退热例数分别为 :观察组 80例 (74.1% ) ,对照组 3 9/ 5 5例 (70 .9% ) ,P>0 .0 5。 4结论　根据 CRP≥ 10 mg/ L 应用抗生素治疗的有效率 ,高于根据血象升高应用抗生素的有效率 ,可能与某些病毒感染初期血象可以略有升高 ,造成临床误认为是细菌感染有关 ,快速定量Objective To study the significance of rapid quantity of CRP in differential diagnosis of children with upper respiratory infection(URI)caused by bacteria or virus.Methods 263 cases with URI were divided into two groups randomly, Quick-Read CRP and blood routine tests were done in test group. The cases were treated with antibiotics when CRP≥10 mg/L, others were treated with antivirotics. Only blood routine tests were done in control group. The cases were treated with antibiotics when WBC≥10×10 9 /L, other with antivirotics. The cases whose temperature declined to normal after 3 days' treatment were recorded.Results The number of cases whose temperature declined to normal after 3 days' treatment was respectively 122 (76.3%) in test group,50 (48.5%) in control group(P<0.001).of which treatment with antibiotics was respectively 40(76.9%) in test group, 21(43.7%) in control group(P<0.01),treatment with antivirotics in two groups was respectively 80(74.1%) in test group, 39/55 (70.9%) in control group(P>0.05).Conclusions The efficiency of antibiotic therapy based on the quantity of CRP is higher than that of based on WBC. Rapid quantity of CRP is reliable to determine the cause of upper respiratory infection.[

关 键 词：C-反应蛋白 上呼吸道感染 细菌 病毒 儿童 

分 类 号：R725.6[医药卫生—儿科] R446.6[医药卫生—临床医学]