妊娠肝内胆汁淤积症孕妇肝功能指标与围生儿预后的关系  

Relationship between maternal hepatic function and fetal prognosis in intrahepatic cholestasis of pregnancy.

作　　者：刘云[1] 漆洪波[1] 李小木[1] 刘健[1] 刘维超[1] 

机构地区：[1]重庆医科大学附属第二医院妇产科,400010

出　　处：《中国实用妇科与产科杂志》2001年第6期350-352,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨妊娠肝内胆汁淤积症 (ICP)孕妇肝功能指标与围生儿预后的关系。方法　对 16 6例ICP孕妇肝功能指标及围生儿预后进行回顾性分析。结果　孕妇血清转氨酶 (ALT、AST)及胆红素 (BIL)水平升高者胎儿窘迫及羊水粪染发生率增加 ,新生儿体重及Apgar评分均与胆红素水平有关 ,通过公式计算可以预测围生儿预后。孕妇胆汁酸 (TBA)升高程度与羊水粪染及胎儿窘迫率无关 ,其它肝功能指标、脐动脉S/D比值及瘙痒时间的长短也与胎儿预后无关。结论　ICP孕妇转氨酶及胆红素水平升高者胎儿预后不佳 ,必须高度重视 。Objective To investigate the relation between hepatic function of mothers and prognosis of fetuses in intrahepatic cholestasis of pregnancy(ICP).Methods Retrospective study of 166 patients with ICP.Results The incidences of meconium passage and fetal distress were perfectly high in mothers of high serum transaminase and bilirubin.The birth weight and Apgar scores of neonate were related to the levels of bilirubin and we could predict the fetal prognosis by analysis of mother's serum bilirubin level.The serum total bile acid(TBA) levels and other hepatic indexes were not related to the incidences of meconium passage and fetal distress.The peak-systolic/diastolic ratio(S/D) of umbilical artery and itching period were not related to the prognosis of fetuses.Conclusion The fetal prognosis of mothers with high-level serum transaminase and bilirubin is bad,so they must be taken great aware of.The prognosis of fetuses can be bettered by cesarean section at proper time.

关 键 词：肝内胆汁淤积症 肝功能 胎儿 妊娠合并症 

分 类 号：R714.255[医药卫生—妇产科学] R575.63[医药卫生—临床医学]