冰片对胰岛素透粘膜吸收的促进作用研究  

An Enhancement Research of Insulin Transmucosal-absorption with Borneol

作　　者：吴庆知[1] 高秋华[1] 朱玉山[1] 徐辉碧[1] 

机构地区：[1]华中科技大学化学系

出　　处：《华中科技大学学报（自然科学版）》2001年第A01期41-43,共3页Journal of Huazhong University of Science and Technology(Natural Science Edition)

摘　　要：考察冰片对胰岛素透口腔粘膜吸收的促进作用 .以SD大鼠为对象 ,以血糖浓度为指标 ,研究不同浓度的冰片对胰岛素透口腔粘膜吸收的促进作用 .研究发现 ,一定浓度的冰片 (0 .12 % )能显著促进胰岛素透口腔粘膜的吸收 (P <0 .0 5 ) ,但由于冰片水溶性极差 ,其剂量依赖性不很明显 ,即增加冰片的量不一定能成比例地促进药物的吸收 .冰片对胰岛素透口腔粘膜吸收有显著促进作用 .Insulin transmucosal absorption tests are performed by measuring the variation of glucose level of blood in SD rats. The transmucosal absorption of insulin ( P <0.05) is significantly enhanced by borneol. There is not a optimal significant dose dependant effect on different constants of Borneol for its insolubility in aqueous solution. The optimal constant of Bornel is 0.12?%. The transmucosal absorption of insulin is effectively enhanced by borneol.

关 键 词：冰片 胰岛素 透粘膜吸收 

分 类 号：Q578[生物学—生物化学]