IL-1β和IL-8在分泌性中耳炎中耳积液中的表达及意义  

The expression of interlenkin-1β and interlenkin-8 in otitis media with effusion and its significance

作　　者：韩朝冬[1] 陈瑛[2] 葛文胜[1] 孙新中[1] 姜保禄[1] 李智深[1] 王领台[1] 杨淑娟[1] 袁英[1] 

机构地区：[1]聊城市人民医院耳鼻喉科,聊城252000 [2]山东大学齐鲁医院耳鼻喉科

出　　处：《山东医大基础医学院学报》2001年第3期174-176,共3页

摘　　要：目的 :探讨IL - 1 β和IL - 8在分泌性中耳炎发生和转归中的作用。 方法 :应用酶联免疫吸附法(ELISA)检测 38例分泌性中耳炎患者 40耳中耳积液中IL - 1 β和IL - 8的含量。 结果 :IL - 1 β和IL - 8在分泌性中耳炎中耳积液中的表达率分别为 80 %和 92 .5% ,早期积液中IL - 1 β和IL - 8的含量高于晚期 (P均<0 .0 0 1 ) ,浆液性积液中二者的含量亦较高 (P <0 .0 0 2 ,P <0 .0 5) ,IL - 8与IL - 1 β的含量呈正相关 (r=0 .83,р <0 .0 1 )。结论 :IL - 1 β和IL - 8是分泌性中耳炎中耳积液形成众多细胞因子中的两种 ,均存在于早期中耳积液中 ,并促进浆液性中耳积液的产生 ,前者对后者的产生有促进作用。Objective:To study the role of interleukin-1β(IL-1β) and interleukin-8(IL-8)in the pathogenesis of otitis media with effusion(OME).Methods:The content of IL-1β and IL-8 in middle ear effusion (MEE) were measured in 38(40 ears ) patients by enzyme linked immunoadsorbent assay(ELISA).Results:The expressive rates of IL-1β and IL-8 were 80% and 92.5% in middle ear effusion respectively. The mean levels (±s) of IL-1β and IL-8 were 11.06±11.02 pg/ml and 2159.55±1031.25 pg/ml . It revealed that the shorter the course,the higher the concentration of IL-1β and IL-8 in MEE . The concentration of the two in serous fluid group was remarkably higher than that in the mucous fluid group(P<0.002,P<0.05). IL-8 level of MEE was positively correlated with IL-1β(r=0.83,P<0.01).Conclusion:IL-1β and IL-8 might be important mediators in MEE secretion in the early stage of OME . They might interact each other .

关 键 词：伴渗出液中耳炎 白细胞介素-1 白细胞介素-8 细胞活素类 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]