车间空气中乙酰甲胺磷卫生标准研究  

Study on the Health Standard for Acephate in the Air of Workplace

作　　者：陈秀凤[1] 吴立仁[1] 吴加罗[1] 吴晓东[1] 曹婉娟 俞永旦[1] 

机构地区：[1]浙江省医学科学院,杭州310013 [2]绍兴市卫生防疫站

出　　处：《劳动医学》2001年第2期78-80,共3页

基　　金：卫生部卫生标准"八五"规划项目 (编号 :3 92 0 85)

摘　　要：[目的 ]研制车间空气中乙酰甲胺磷的国家卫生标准。 [方法 ]乙酰甲胺磷动物毒性试验及接触工人的职业流行病学调查。[结果 ]乙酰甲胺磷大鼠经口LD50 为 82 3mg/kg。致突变性试验、致畸试验及迟发性神经毒性试验均为阴性。车间空气中乙酰甲胺磷浓度测定大多数在 0 5mg/m3 以下 ,未发现接触工人有中毒症状。[结论 ]建议车间空气中乙酰甲胺磷的最高容许浓度为 0 5mg/m3,其时间加权平均容许浓度为 0 3mg/m3。Objective] To establish national health standard for acephate in the air of workplace.[Method]Occupational epidemiological investigation in field and animal experiments were performed to study the toxicity of acephate. [Results] LD 50 for acephate by intragastric administration is 823 mg/kg in rats. Negative effects were obtained in experimental assays of mutagenicity,teratogenicity and delayed neurotoxicity.The results of determination showed that most of the acephate concentrations in the air of workplaces were below 0 5 mg/m 3.The signs of adverse effects of acephate poisoning in workers were not fuond. [Conclusion] The maximum allowable concentration(MAC) and the time weighted average allowable concentration(TWA AC) were recommended as 0 5 mg/m 3 and 0 3 mg/m 3,respectively.

关 键 词：乙酰甲胺磷 毒理 最高容许浓度 时间加权平均容许浓度 卫生标准 车间空气 

分 类 号：R134.3[医药卫生—劳动卫生]