车间空气中尿素卫生标准的研究  

Study on the Health Standard for Urea in the Air of Workplace

作　　者：吴立仁[1] 陈秀凤[1] 吴加罗[1] 顾学林[2] 余延山 俞永旦[1] 

机构地区：[1]浙江省医学科学院,杭州310013 [2]镇海炼油化工股份有限公司 [3]衢化集团公司

出　　处：《劳动医学》2001年第2期99-100,共2页

基　　金：卫生部卫生标准"八五"规划项目 (编号 3 92 1 0 5)

摘　　要：[目的 ]研究车间空气中尿素的国家卫生标准。 [方法 ]现场接触工人的职业流行病学调查。尿素的急性及慢性毒性试验。收集国内外有关资料。 [结果 ]尿素的大鼠经口LD50 为 8471mg/kg。大鼠吸入慢性阈浓度为 (45 9± 9 8)mg/m3。车间空气中尿素浓度在 10mg/m3,未发现接触工人有中毒症状。 [结论 ]建议车间空气中尿素的最高容许浓度为10mg/m3,其时间加权平均容许浓度为 5mg/m3。Objective] To establish national health standard for urea in the air of workplace. [Methods] Occupational epidemiological investigation and sudies on the acute and chronic toxicity of urea were conducted. The available materials concerning standard setting were collected. [Results] LD 50 for urea by intragastric administration is 8 471 mg/kg in rats. The threshold of chronic toxic effect in rats is (45 9±9 8)mg/m 3. The results of determination showed that the concentrations of urea in the air of workplace were below 10 mg/m 3. The adverse effects of urea in exposed workers were not found. [Concentration] The maximum allowable concentration(MAC) and the time weighted average allowable concentration(TWA AC) have been recommended 10 mg/m 3,respectively.

关 键 词：尿素 毒理 最高容许浓度 时间加权平均容许浓度 车间空气 

分 类 号：R134.4[医药卫生—劳动卫生]