中国云南省西双版纳使用氯喹治疗恶性疟失败的高危因素(英文)  

CASE-CONTROL STUDY ON THE RISK FACTORS FOR TREATMENT FAILURE OF FALCIPARUM MALARIA TREATED BY CHLOROQUINE IN XISHUANGBANNA, YUNNAN, CHINA

作　　者：张再兴[1] 杨亚明[1] 李崇珍[1] 黄国珍[1] 周升[1] 孙小东[1] 李丽[1] 

机构地区：[1]云南省疟疾防治研究所,云南思茅665000

出　　处：《中国寄生虫病防治杂志》2001年第2期87-89,共3页Chinese Journal of Parasitic Disease Control

基　　金：Supported by WHO/ TDR

摘　　要：目的　寻找在中国云南省边境地区氯喹治疗恶性疟失败的高危因素。　方法　在现场开展病例对照研究 ;采用 WHO对无并发症药物的治疗疗效指南 ;用单因素和多因素 logistic回归分析法进行数据分析。　结果及结论　发现两个独立的高危因素 ,即在 10 0 0 / μl以上的无性体原虫密度和受教育水平。这二者的发现有着十分重要的意义 ,前者对病人是危险因素 ,而后者使其具有保护作用。Objective To detect the risk factors for treatment failure of chloroquine against falciparum malaria in the border area in Yunnan, China. Methods Case-control study was carried out in the field. WHO guideline for assessment of therapeutic efficacy of antimalarials for uncomplicated falciparum malaria was followed. Univariate and multivariate logistic regression was performed to statistically analyze the data. Results and Conclusion Two independent risk factors, asexual parasitaemia density of over 1000/μl and educational level, were found. The former resulted in patients at risk and the later was protective.

关 键 词：危险因素 治疗失败 疟疾 氯喹 

分 类 号：R531.305[医药卫生—内科学]