低剂量米非司酮作为紧急避孕药的临床效果观察  

Clinical effective observation on low Dose Mifepristone as an emergency contraceptive

作　　者：于玲[1] 杨小玉[2] 王晖[1] 程渭玉[1] 

机构地区：[1]天津市计划生育研究所,300191 [2]天津市职工医学院

出　　处：《天津医科大学学报》2001年第2期165-167,共3页Journal of Tianjin Medical University

基　　金：世界卫生组织人类生殖健康特别规划署资助

摘　　要：目的 :探索低剂量米非司酮作为紧急避孕药的临床效果。方法 :给予100例月经规则 ,性生活时未采取避孕措施或避孕措施失败后72h内的妇女 ,口服一次10mg米非司酮 ,避孕有效率按Dixon预期妊娠概率计算。结果 :1例妊娠 ,避孕有效率为86.38 %。副反应发生率仅16 % ,程度轻微。下次月经周期无变化者为86.87 % ,周期延迟则占9.09 %。与平时月经经期和经量相似者分别为90.9%和88.9 %。结论 :低剂量米非司酮是安全。Objective: To study the clinical effectiveness of low dose mifepristone as an emergency contraceptive. Methods:One humdred women with regular menstrual cycles who had unprotected intercourse or contraceptive failure were asked to take a single dose of 10 mg mifepristone within 72 hours. Contraceptive efficacy was calculated by Dixons method. Results:One pregnancy occurred. Contraceptive efficacy rate of preventing pregnancy was 86.38%. The incidence of various side effects was only 16.0% which were mild. The percentage of subjects who had normal menstrual cycle was 86.87%. 9.09% of subjects' had prolonged menstrual cycles.The percentages of subjects who had similar menstrual period and amount of menses were 90.9% and 88.9% respectively. Conclusion:Low dose mifepristone for emergency contraception is a safe, effective way of modern emergency contraceptive.

关 键 词：避孕 紧急避孕 米非司酮 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R979.21