血清总胆红素浓度与冠心病关系探讨  

Clinical investigation on the relationship between the level of total bilirubin and coronary heart disease

作　　者：殷雅琴[1] 梁伯平[1] 罗玮[1] 孙广山[1] 

机构地区：[1]天津市胸科医院心内科,300051

出　　处：《天津医科大学学报》2001年第2期256-258,共3页Journal of Tianjin Medical University

摘　　要：目的 :探讨血清胆红素与冠心病的关系。方法 :将117例已行冠状动脉造影患者分为冠心病组 (狭窄≥50 % )及对照组 (狭窄<50 % ) ,比较两组间血清总胆红素浓度 ,并对胆红素与多种因素进行直线相关及回归分析。结果 :冠心病组血清总胆红素浓度明显低于对照组 (P<0.001)。血清总胆红素浓度与冠脉狭窄积分 (P=0.0007)、TC/HDL -c(P=0.0069)、LDL -c/HDL -c(P=0.0178)呈明显负相关 ,与HDL -c(P=0.0225)呈明显正相关。结论 :低血清胆红素可能是冠心病一种新的危险因素。Objective: To study the relationship between the level of serum total bilirubin and coronary heart disease. Methords:One hundred and seventeen patients undergoing diagnostic coronary angiography were divided into two groups: the CHD group (≥50% diameter narrowing) and the control group (<50% diameter narrowing), then comparison was done between the two groups of the level of serum total bilirubin.Liner regression and correlation analysis was also done between serum bilirubin and other factors. Results: The level of serum total bilirubin of the CHD group is much lower than that of the control group(P<0.001).The linear regression analysis showed positive correlation of the level of serum total bilirubin with coronary stricture (P=0.0007), TC/HDL-c(P=0.0069), LDL-c/HDL-c(P=0.0178) and negative correlation with HDL-c(P=0.0225). Conclusion: Low level of serum bilirubin may be a new dangerous factor for coronary heart disease.

关 键 词：胆红素 氧化修饰低密度脂蛋白 冠状血管造影 冠状动脉疾病 

分 类 号：R541.402[医药卫生—心血管疾病]