三磷酸肌醇影响钙释放的数学模型研究  

A STUDY OF MATHEMATICAL MODEL FORINOSITOL-1.4.5-TRIPHOSPHATE-INDUCED Ca^(2+) OSCILLATIONS

作　　者：杨华[1] 陈良怡 齐欢[1] 吴鸿修[2] 

机构地区：[1]华中科技大学数学系,湖北武汉430074 [2]华中科技大学生物物理与生物化学研究所

出　　处：《生物物理学报》2001年第2期344-350,共7页Acta Biophysica Sinica

摘　　要：此模型主要说明激动剂诱发的Ca2 +振荡实验中Ca2 +释放的若干特征。模型假设内质网(ER)上三磷酸肌醇(IP3)受体/Ca2 +通道是由相互独立的三亚基组成 ,每个亚基可以结合IP3 或促进或抑制Ca2 + 释放。可看出IP3 受体/Ca2 + 通道随Ca2 + 变化成钟形反应、随IP3 的变化呈上升趋势。Ca2 + 振荡的频率和振幅与Ca2 + 依赖性IP3 的最大泵入速率 (v6)有很大关系。当Ca2 + 振荡对v6变化较敏感时 ,Ca2 + 振荡的振幅与v6 有近似的线性关系。扩展的模型可分析IP3 对钙依赖不同程度下的情况。This article mainly illustrates the character of Ca2+ release in the model of agonist-stimulated Ca2+ oscillations. The model assumes that IP3(inositol-1.4.5-triphosphate)-receptor/Ca2+-channel consists of three independent subunit which may bind to IP3, activate or inhibit Ca2+ release. The prolate model can explain oscillation in many kinds of cells. When the IP3 concentration remains stable, by varying intracellular Ca2+ level, the bell shape curve of the open probability of IP3-receptor/Ca2+-channel could be observed. The frequency and amplitude of Ca2+ are in close ship with maximum Ca2+ dependent IP3 rate(v6). When Ca2+ oscillations are sensitive to v6, the relation between the amplitude of Ca2+ and v6 can be represented as a straight line approximately.

关 键 词：IP3 Ca^2+振荡 振荡参数 钙释放 细胞 

分 类 号：Q26[生物学—细胞生物学] Q612