吸烟、饮酒的糖尿病危险性分析  

Cigarette smoking, alcohol use, and the risk of diabetes in Guangdong population

作　　者：广东省糖尿病流行病学调查协作组 邝建[1] 杨华章[1] 崔炎棠[1] 

机构地区：[1]广东省人民医院内分泌科,广州510080

出　　处：《广东医学》2001年第6期459-462,共4页Guangdong Medical Journal

基　　金：广东省科委重点攻关资助!课题 (编号 :A0 0 0 0 971 52 )

摘　　要：目的　了解吸烟、饮酒在糖尿病发病风险中的作用 ,及其对糖尿病及IGT患者餐后血糖、血压、BMI及WHR的影响。方法　利用广东省 1998对全省 11742名抽样人群进行的糖尿病流行病学调查数据 ,做多元Logistic回归分析和广义线性模型方差分析。结果　调查人群中 ,糖尿病主要独立预测因素为年龄 (OR =2 0 5 3,1 5 6 8～ 2 6 87)、家族史 (OR =3 2 10 ,2 0 19～ 5 10 4)、职业运动量 (OR =1 6 44 ,1 2 17～ 2 2 2 1)、WHR(OR =2 2 5 5 ,1 6 90～ 3 0 0 8)、BMI(OR =2 5 38,1 90 5～ 3 381)和高血压 (OR =3 0 88,2 2 46～ 4 2 45 )。吸烟和饮酒的独立风险作风不显著 ,调整年龄、运动、家族史、经济水平等其他因素后 ,每日吸烟 >2 5支或每周饮酒 >7次的相对危险度 (OR)分别为 1 0 37(0 36 7～ 1 5 35 )和 1 2 6 1(0 718～ 2 2 14)。但吸烟、饮酒和年龄、职业运动量及家族史有明显的相乘交互作用 ,每日吸烟 >2 5支明显增加 5 0岁以上人群和低职业运动量人群的糖尿病患病风险 ,每周饮酒 >7次除增加职业运动量较低人群患病风险外 ,使 5 0岁以下人群的患病危险性增加 1 42倍 ,并大幅增加有糖尿病家族史人群的相对危险性 (OR =8 6 1,2 14～ 34 6 3)。在糖尿病及IGT患者中 ,当前吸烟者的BMI低于已戒烟和不?Objective To examine the association between smoking, alcohol consumption and the risk of diabetes and the impacts of smoking and alcohol on postprandial plasma glucose(PG), blood pressure, body mass index(BMI) and waist-to-hip ratio(WHR) in patients with diabetes and IGT.Methods Data from 1998 Guangdong provincial diabetes interview survey, a population-based cross-sectional study including. 11 767 residents aged 20～74 years[male 5 462 , female 6 305 ,mean age (43.8±13.6) years], was used for analysis. Standard oral glucose tolerance test(75 g) and physical examination were conducted on all subjects. Questionnaire included questions about physical activity, family history, economic state, average daily consumption of alcohol and cigarette, etc. Multivariate logistic regression and GLM-General factorial analysis were used. Results In Guangdong population, the main independent predictive factors of diabetes were age (OR=2.053, 1.568～2.687), family history (OR=3.210, 2.019～5 104), exercise (OR=1.644, 1.217～2.221), BMI(OR=2.538, 1.905～3.381), WHR(OR=2.255,1.690～3.008) and hypertension(OR=3.088, 2.246～4.245). Affer adjusted for age, physical activity, family history and economic state, the odds ratio of smoking>25 cigarettes a day was 1.037(0.367～1.535), drinking>7 times per week was 1.261(0.718～2.214); but there were significant interaction between smoking or drinking and age, family history or exercise condition, after controlling for confounders, the odds ratios of diabetes were 3.910(1.953～7.826) for smoking>25 cigarettes a day and age>50 years, 2.251(1.144～4.431) for smoking>25 cigarettes a day and lower physical activity, 2.421(1.130～5.185) for drinking>7 times per week and age<50 years, 8 608(2.140～34.631) for drinking>7 times per week with family history. Among the patients with diabetes or IGT, current smoking had higher WHR but lower BMI than never and ever smoker, current drinker only had lower BMI than ever drinker. Conclusion Either heavy smoking or drinking m

关 键 词：吸烟 饮酒 糖尿病 危险因素 IGT 

分 类 号：R587.1[医药卫生—内分泌] R163[医药卫生—内科学]