肥胖对老年糖尿病患者血清胰岛素及C肽释放水平的影响  

Effetct of obesiy on serum insulin and C-peptide releasing level in aged diabetic patients

作　　者：孙丽明[1] 鄢淑鑫 赵维[3] 

机构地区：[1]沈阳医学院附属中心医院内分泌科,辽宁沈阳110024 [2]沈阳变压器厂职工医院 [3]1沈阳医学院附属中心医院内分泌科,辽宁沈阳110024

出　　处：《中国实验诊断学》2001年第3期130-131,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　测定老年糖尿病 (DM )患者血清胰岛素 (INS)及C肽 (C P)水平 ,探讨二者与肥胖的关系。方法　肥胖组18例 ,非肥胖组 2 4例 ,对照组为 14例健康老人。用氧化酶法测血糖 ,放射免疫法 (RIA)测血清INS及C P ,计算胰岛素敏感指数 (ISI)。结果　老年DM非肥胖组试餐后血清INS水平低于对照组。ISI(0 0 2 0 1± 0 0 12 9)略低于对照组 (0 0 30 9±0 0 12 4) ,P <0 0 5。老年糖尿病肥胖组空腹INS及C P(36 84± 10 94IUL ;6 0 6± 1 6 8nmolL)明显高于对照组 (12 2 1± 4 12 ;1 85± 0 6 7) ,P <0 0 1。口服葡萄糖耐量实验 (OGTT)后血清INS及CP应达相同 ,显示高峰延迟和持续升高两种曲线类型。ISI(0 0 0 44± 0 0 0 2 2 )显著低于对照组 ,P <0 0 1。结论　肥胖是老年糖尿病患者高胰岛素血症。Objective\ To detect serum insulin (INS)and C-Peptide(C-P)releasing levels in aged diabetic patients and, to discuss the effect of obesity on them. Methods\ Serum INS and C-P from obesity group 18 cases,non-obesity group 24 cases, control grorp healthy elders 14 cases were measured with radioimmunoassay(RIA),and the insulin sensitive index(ISI)was calculated.Results DM serum INS releasing lebels of 24 non obesity group aged after OGTT,ISI(0 0201±0 0129)was Lower than contrast group(0 0309±0 0124)( P <0 05).18 obesity aged diabetic patient'sfasting INS and C-P (36 84±10 94IUL;6 06±1 68nmolL)were dominant highter that thore of contrast group(12 2±1 41±21 85±0 67nmolL)( P <0 01).Serum INS and C-P after OGTT were on the same levels.which indicated 2 types of curve's peak were prolonged and elevated continrously.Compared with contrast group ISI (0 0044±0 0022)wasower significantly( P <0 01)。Conclusion Obesity is the factor of elderly diabetic petient's hyperinsulinemia and insulin resistance

关 键 词：肥胖 糖尿病 血清胰岛素 C肽 老年人 

分 类 号：R587.1[医药卫生—内分泌]