唾液析晶形态试验在诊断舍格伦综合征中的应用  

Evaluation of saliva ferning test in diagnosis of Sjgren′s syndrome

作　　者：丁玲[1] 唐燕[1] 陆群[1] 

机构地区：[1]上海第二医科大学附属仁济医院口腔科,200001

出　　处：《中华口腔医学杂志》2001年第3期174-176,T002,共4页Chinese Journal of Stomatology

摘　　要：目的　探讨唾液析晶形态试验 (salivaferningtest,SFT)在舍格伦综合征 (Sj gren′ssyndrome ,SS)诊断中的价值。方法　共收集 78例确诊为SS的患者 (采用欧洲标准 ) ,在进行唇腺活检之前取非刺激性新鲜唾液 ,光镜下观察其结晶形态 ,根据Maragou标准记录分型 ,根据Tarpley标准记录唇腺活检结果 ,并比较两种方法的阳性检出结果。同期随机选择 80名健康人设为对照组 ,观察唾液析晶形态 ,检测SFT的敏感性和特异性。结果　①SFT具有较高的敏感性 (89 74% )和特异性(83 75 % )。②SFT阳性结果在SS病例组和对照组比较差异有显著性 (P <0 0 1)。③SFT和唇腺活检在病例组的阳性检出结果差异无显著性 (P >0 0 5 )。结论　SFT对SS患者的早期诊断及治疗具有重要的参考价值。Objective To evaluate saliva ferning test in (SFT) diagnosis of xerostomia in patients with Sjgren′s syndrome (SS). Methods Dried samples of freshly produced saliva from 78 patients diagnosed as SS according to european community criteria and 80 healthy controls were examined by light microscopy. The crystallization was classified into 4 types according to the ferning phenomenon: uniformity, branching, spreading and integrity (type Ⅰnormal and typeⅡ, Ⅲ, Ⅳ abnormal). Then, the 78 patients underwent labial salivary gland biopsy. According to Tarpley′s classification of labial gland biopsy, ≥2+ was considered positive. Results (a) The sensitivity and specificity of SFT were 89 74% (70/78) and 83 75% (67/80) respectively. (b) Abnormal SFT was observed in 70/78 (89 74%) of SS and in 13/80 (16 25%) of normal controls. The differences of SFT in SS patients versus normal controls were significant ( P< 0 01). (c) The sensitivity of SFT and labial gland biopsy had no significant differences ( P> 0 05) as diagnostic tests in SS. Conclusions SFT was valuable as a diagnostic test in patients suspective of SS.

关 键 词：唾液析晶形态试验 常规诊断试验 舍格伦综合征 干燥综合征 

分 类 号：R442.8[医药卫生—诊断学]