过氧化体增殖剂激活的受体及其功能  

Peroxisome Proliferator-activated Receptors and Their Functions

作　　者：焦鸿丽[1] 叶平[2] 赵保路[1] 

机构地区：[1]中国科学院生物物理研究所,北京100101 [2]中国人民解放军总医院老年心内科,北京100853

出　　处：《生物化学与生物物理进展》2001年第4期478-481,共4页Progress In Biochemistry and Biophysics

摘　　要：过氧化体增殖剂激活的受体 (PPARs)是 1990年发现的核激素受体家族的一个新成员 .其三种亚型α、β、γ具有配体特异性和组织分布的特异性 .PPARs在控制炎症反应、脂质代谢、细胞增生和分化等方面发挥重要作用 ,研究表明PPARs与一些慢性疾病如癌症。The peroxisome proliferator-activated receptors (PPARs), new members of nuclear hormone receptors were discovered in 1990. Recent developments regarding these receptors were reviewed. The specificity of ligands, the differential tissue distribution as well as target genes are described for each of the three isotypes alpha, beta, gamma. Their implication in the control of inflammtory response, lipid metabolism, cell proliferation and differentiation, and the possible role played in chronic diseases' such as cancer and atherosclerosis are discussed.

关 键 词：过氧化体增殖剂激活 受体 氧应激 脂质代谢 炎症 疾病 

分 类 号：R962[医药卫生—药理学] R361[医药卫生—药学]