伤寒Vi多糖菌苗稳定性研究  

The stability study of Salmonella typhoid Vi polysaccharide vaccine

作　　者：张河战[1] 王斌[1] 计国欣[1] 

机构地区：[1]中国药品生物制品检定所,北京100050

出　　处：《微生物学免疫学进展》2001年第3期18-19,共2页Progress In Microbiology and Immunology

摘　　要：为研究国产伤寒Vi多糖菌苗的稳定性 ,将保存三年以上的伤寒Vi多糖菌苗成品采用自然风干和 37℃恒温干燥两种方法浓缩后 ,用CL 4B柱层析分析系统 ,测定KD在 0 2 5前多糖的回收率 ,结果均大于 5 0 %。同时对保存三年以上的制品按规程进行了全检 ,结果均符合规程要求。表明国产菌苗放置三年依然合格。To study native preparation of Vi polysacharide vaccines,the final products of the vaccine were condensed by natural dry or heat at 37℃.The molecular weight of the polysaccharide was determined by the CL 4B gel filtration.The percentage of collection of polysaccharide eluted before 0.25 Kd were all more than 50%.It demonstrated that in three years storage the quality of final products were all in Conformity to 'the requirements for Vipolysaccharide typhoid vaccine'.

关 键 词：伤寒VI多糖菌苗 稳定性 保存期 

分 类 号：R37[医药卫生—病原生物学]