急性重度有机磷农药中毒胃黏膜pH值监测的意义  

Changes in gastric intramucosal pH and its clinical significance in patients with acute severe organophosphorus pesticide poisoning

作　　者：张在其[1] 梁仁[1] 黄韬[1] 蒋德英[2] 杨华喜[2] 尹芙蓉[2] 易高[2] 周玉淑[3] 

机构地区：[1]广东药学院,广东广州510224 [2]湖南省怀化市第二人民医院 [3]中国医学科学院北京协和医院

出　　处：《中国危重病急救医学》2001年第6期354-355,共2页Chinese Critical Care Medicine

基　　金：湖南省怀化市自然科学基金!资助项目 (No.990 5 18)

摘　　要：目的 :探讨胃黏膜内 p H值 (p Hi)监测在急性重度有机磷农药中毒 (ASOPP)中的应用及临床意义。方法 :2 8例 ASOPP患者在洗胃后立即经鼻插入 TRIP NGS导管测定 p Hi,以后每 12小时监测 1次 ;另以 12例健康者为对照。结果 :在 ASOPP未并发急性呼吸衰竭 (ARF)时 ,患者的 p Hi就明显降低 (P<0 .0 5 ) ,而此时全身氧供指标——动脉氧分压 (Pa O2 )无明显改变 (P>0 .0 5 ) ;在 ASOPP并发 ARF时 ,患者的 p Hi比 Pa O2 降低得更明显。结论 :p Hi监测对早期发现 ASOPP患者局部组织缺氧及采取措施预防Objective:To investigate the clinical significance of monitoring gastric intramucosal pH (pHi) in patients with acute severe organophosphorus pesticide poisoning (ASOPP).Methods:Twentyeight patients with ASOPP were enrolled in this study.Their pHi values were measured using a TRIPNGS tube through nasal cavity immediately after gastric lavage and every 12 hours interval.Results:The pHi values in patients with ASOPP were significantly low before acute respiratory failure (ARF) developed ( P <0 05),while the level of oxygen delivery (PaO 2) was normal ( P >0 05).After ARF developed,the pHi values were much lower compared with the decrease in PaO 2.Conclusions:The pHi measurement is of clinical significance in the early detection of ischemia in internal organs and in the prevention of ARF as well as multiple organ failure in patients with ASOPP.

关 键 词：有机磷农药中毒 胃黏膜内pH值 呼吸衰竭 急性 

分 类 号：R595.4[医药卫生—内科学]