自体脂肪、筋膜移植用于声带填充术的实验研究  

Vocal Fold Augmentation by Transplantation of Autologous Fat and Fascia: An Experimental Study

作　　者：李明栋[1] 隋军[1] 王文慧[1] 何晓光[1] 叶聪俊[1] 

机构地区：[1]昆明医学院第一附属医院耳鼻咽喉科

出　　处：《听力学及言语疾病杂志》2001年第3期142-144,共3页Journal of Audiology and Speech Pathology

摘　　要：目的　应用自体脂肪、筋膜行声带填充治疗单侧声带麻痹，探讨这两种填充材料的疗效及应用前景。方法实验动物为狗，分为２组，Ａ组２只分别以自体脂肪、筋膜行声带填充矫治左侧带麻痹而致的声门闭合不全，于术后８个月取材行透射电镜及光镜观察；Ｂ组９只分别于左侧声带植入自体脂肪，右侧声带植入自体筋膜各０．４ｍｌ，分别手术后１、３、５个月取材行光镜观察。结果　自体脂肪能存活于声带组织中，但吸收较明显，功能观察显示，疗效维持不超过５个月；自体筋膜可成功存活于声带，疗效可维持８个月以上。结论　自体脂肪吸收明显，疗效不能持久，仅能作为短期的声带填充材料；自体筋膜性质较为稳定，疗效持久，具有良好的应用前景。Objective To compare the histological fates and the effects of autologous fat and fascia used as augmentative materials to treat unilateral vocal fold paralysis (UVFP). Methods Vocal fold augmentation with autologous fat and fascia was performed on 2 dogs (group A) to cure glottic insufficiency caused by left vocal fold paralysis. Autologous fat and fascia 0.4 ml were injected respectively into left and right vocal folds of 9 dogs (group B). The dogs of group B were killed after 1,3 and 5 months and the dogs of group A were killed after 8 months. The histology of both substances and the effect of treatment were evaluated. Results Surviving autologous fat grafts was found in the canine vocal fold after 8 months, but the absorption was too rapid to maintain the bulk of grafts, the effect could last no more than 5 months. Autologous fascia also survived after 8 months, Conclusion The results showed that these two augmentative materials were both effective in the treatment of IJVFP. Autologous fat can only be used as short - term augmentative material. However, autologous fascia has a potential use for long - term application to correct glottic insufficiency caused by UVFP and other diseases.

关 键 词：声带麻痹 脂肪 筋膜 自体移植 声带填充术 

分 类 号：R767.4[医药卫生—耳鼻咽喉科]