清洁手术预防性应用抗生素1∶1病例对照研究  

Preventive Use of Antibiotics in Sterile Surgery

作　　者：李宁[1] 李有信[1] 冯喆[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中华医院感染学杂志》2001年第4期247-248,共2页Chinese Journal of Nosocomiology

摘　　要：目的　分析清洁手术预防性应用抗生素规范化方案的临床效果及医疗费用合理支出的可行性。方法　采用病例对照分析方法 ,对 149例清洁手术采用术前、术中、术后短期规范化应用抗生素 ,预防手术部位感染的方法与术后用药并延长给药时间 (>3d)的方法 ,进行 1∶ 1对照比较 ,进行临床疗效和经济学分析评价。结果　证实前者使医院感染率降低 ,耐药菌群产生减少 ,缩短了平均住院日并使医疗费用降低。结论　本研究采用清洁手术应用抗生素预防感染的规范方案 ,具有显著的临床意义 ,方法科学 ,效果显著 ,实用性及可操作性较强。OBJECTIVE To analyze the clinical effectiveness and costs of the standardized preventive use of antibiotics in sterile surgery. METHODS A case control study was performed with 149 cases in the control and experimental groups, respectively. The experimental group was given antibiotics at the surgery site before, during, and shortly after operation to prevent infection, while the control one was given antibiotics for a more prolonged period (>3 d) after operations. Clinical and economic effectiveness was analyzed. RESULTS The experimental group had lower infection rates, showed less drug resistance, and had shorter hospitalization and lower medical costs. CONCLUSIONS This study demonstrated that the standardized and preventive use of antibiotics in sterile surgery has clinical significance. It is effective, practical and applicable.

关 键 词：清洁手术 预防性应用抗生素 病例对照研究 

分 类 号：R61[医药卫生—外科学]