益肾降浊汤对大鼠缺血再灌注脑组织乙酰胆碱酯酶活力的影响  

EFFECT OF YISHENJIANGZHUO DECOCTION ON INTRACEREBRAL ACHE ACTIVITY OF ISCHEMIA REPERFUSION RAT

作　　者：袁国红[1] 高维娟[1] 孟凡星[1] 郎志峰[1] 

机构地区：[1]承德医学院病理生理学教研室,河北承德067000

出　　处：《承德医学院学报》2001年第2期102-104,共3页Journal of Chengde Medical University

基　　金：河北省科委科研基金资助课题 (课题号 :982 761 87D)

摘　　要：目的 :探讨益肾降浊汤对大鼠脑缺血再灌注脑内乙酰胆碱酯酶 (Ach B)活力的影响。方法 :在造成大鼠低血压的基础上 ,进行脑缺血再灌注 ,用水迷宫法测定大鼠的行为学 ,比色法测脑海马 Ach B活力。结果 :模型组大鼠出现明显学习记忆障碍 ,Ach B活力升高 ,中药组大鼠学习记忆成绩明显好于模型组(P<0 .0 1) ,Ach B活力低于模型组 (P<0 .0 5)。结论 :益肾降浊汤可降低大鼠脑缺血再灌注后脑组织Ach B活力 ,改善学习记忆障碍。Objective:To investigate the effect of YiShenJiangZhuo decoction on intracerebral AchE activity of ischemia reperfusion rat.Methods:After preparing a model of ischemia-reperfusion based on hypotension,we observed the praxiology of rat by using water labyrinth test and AchE activity of hippocampus by colorimetric method.Results:The model rat had distinct disturbances of learning and remembrance the Ache activity increased.The result of learning and remembrance in YiShenJiangZhuo decoction group improved significantly (P<0.01)compared with the model rat;And AchE activity in YiShenJiangZhuo decoction group significaitly decreased(P<0.05).Conclusion:It is suggested that the YiShenJiangZhuo decoction can improve the learning and remembrance by decreasing the AchE activity of ischemia reperfusion

关 键 词：益肾降浊汤 脑缺血再灌注 乙酰胆碱酯酶活力 中医药疗法 

分 类 号：R277.733[医药卫生—中医学]