房颤患者血浆vWF、TAT水平测定及临床意义  

Measurement and Clinical Significance of Plasma vWF and TAT in Atrial Fibrillation Patients

作　　者：孙燕淑[1] 祁芸芸[1] 

机构地区：[1]北京大学第一医院内科,北京100034

出　　处：《中国医药导刊》2001年第3期200-201,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨心房纤颤患者血浆血栓前状态分子标志物——血管性假血友病因了(vWF)及凝血酶-抗凝血酶Ⅲ复合物(TAT)的变化及其临床意义。方法:采用ELISA法测定27例非瓣膜病房颤患者血浆vWF、TAT浓度,并与25例窦性心律者比较。结果:(1)房颤组血浆vWF水平较对照组明显升高(P<0.01)。(2)房颤组血浆TAT水平较对照组明显升高(P<0.05)。结论:房颤可引起内皮细胞功能损伤并激活凝血系统,房颤患者处于血栓前状态。检测房颤患者血浆中血栓前状态分子标志物可成为评估房颤患者栓塞危险性的新手段。Objective: To study the alterations and clinical significance of plasma prothrombotic molecular markers vWF and Throm-bin - antithrombin Ⅲ complexes(TAT) levels in atrial fibrillation (AF) patients. Methods: Plasma vWF and TAT were determined in 27 patients with nonvalvular atrial fibrillation and 25 volunteer with sinus rhythm by an enzyme linked immunosorbent assay (ELISA) . Results: (1) Plasma vWF levels in patients with AF were significantly higher than those in controls (P < 0.01) . (2) Plasma TAT levels in patients with AF were significantly higher than those in controls (P < 0.05) . Conclusion: Atrial fibrillation can resaut in lesion of endothelium cells and activation of coagulation system, Patients with AF are in a prethrombotie state (PTS). To detect plasma prethrombotic molecular markers in AF patients may become a new means in evaluating embolic risk in AF patients.

关 键 词：心房纤颤 VWF TAT 血栓前状态 

分 类 号：R541.75[医药卫生—心血管疾病]