维持恒定SEF普鲁卡因对七氟醚呼末浓度的影响  

The influence of intravenous procaine infusion to end-tidal sevo flurane concentration during hold constant SEF

作　　者：耿智隆[1] 张宏[2] 靳冰[2] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050 [2]解放军总医院

出　　处：《西北国防医学杂志》2001年第2期135-136,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :应用七氟醚～氧化亚氮 -氧气维持SEF 9～ 11Hz一段时间后 ,静滴普鲁卡因观察维持SEF恒定所需七氟醚呼末浓度的变化。方法 :8例ASAⅠ～Ⅱ级行择期非开胸手术病人 ,诱导气管插管后 ,调整呼末七氟醚浓度使SEF降至 9～ 11Hz,并维持此水平 1h后 ,以 1mg·kg-1·min-1的速率静滴普鲁卡因 ,30min后调整呼末七氟醚浓度使SEF继续维持 9～ 11Hz。结果 :在未静滴普鲁卡因前 ,维持SEF在 9～ 11Hz所需七氟醚浓度为 1.6 2 %± 0 .0 4%。静滴 1%普鲁卡因 30min后 ,维持SEF在 9～ 11Hz所要七氟醚浓度为 1.32 %± 0 .0 7% ,约下降 2 0 %。结论 :在临床常用剂量 ,普鲁卡因对大脑的抑制作用轻微。Objective:To examine the changes of end ti dal sevoflurane concentration to hold a constant EEG spectral edge frequence(SEF 9-11 Hz) during continuous procaine infusion.Methods:[WT5BZ ]Eight patients,ASA Ⅰ～Ⅱ,scheduled for no thoracic operations were included .After intubation,end tidal sevoflurane concentrations were regulated so that S E F was held between 9 and 11 Hz for at least 1 hour,then 1% procaine was infused intravenously at a rate of 1mg·kg -1 ·min -1 .After continuous proc aine infusion for 30 min,end tidal sevoflurane concentrations were again regula ed so as to hold constant SEF between 9 and 11 Hz. Results:End tidal sevoflurane concentrations to hold SEF between 9 and 11 Hz were 1.6 2%±0.04% before intravenous procaine infusion and were 1.32%±0.07%,reduce d about 20%,after intravenous procaine infusion for 30 min.Concl usio n:The inhibitive effect of procaine to brain is weak in clinical c ommon doses.

关 键 词：麻醉学 普鲁卡因 七氟醚 呼末浓度 SEF 

分 类 号：R614.2[医药卫生—麻醉学]