当归多糖增强放射损伤小鼠胸腺细胞增殖及红细胞C3b受体粘附功能的实验研究  

Effect of Angelica Polysaccharide on the Promotion of Thymocyte Proliferation and RBC C3bR Immune Adhesion Function in Radiated Mice

作　　者：洪艳[1] 刘君炎[2] 张渝侯[1] 王红玲[1] 邓子牛[3] 

机构地区：[1]武汉大学中南医院儿科 [2]武汉大学免疫学教研室 [3]武汉大学中南医院中心实验室,湖北武汉430071

出　　处：《中国当代儿科杂志》2001年第3期250-252,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的　进一步探讨当归多糖 (Angelicapolysaccharide,AP)的药用价值。 方法　检测正常对照组、放射对照组及放射 +当归多糖治疗组 3组的刀豆蛋白A(ConA)诱导的胸腺细胞增殖反应和红细胞C3b受体花环率。结果　放射对照组胸腺细胞OD值和红细胞C3b受体花环率 [(0 .2 4± 0 .0 1) ,(16 .46± 0 .76 ) % ]明显低于正常对照组 [(0 .35± 0 .0 1) ,(2 2 .30± 1.2 6 ) % ],而放射 +当归多糖治疗组的胸腺细胞OD值和红细胞C3b受体花环率 [(0 .31± 0 .0 1) ,(2 1.0 7± 1.2 2 % ) ]显著高于放射对照组 [(0 .2 4± 0 .0 1) ,(16 .46± 0 .76 ) % ],P <0 .0 1,有统计学意义。结论　当归多糖能明显增强放射损伤小鼠的胸腺细胞增殖和红细胞C3b受体免疫粘附功能。Objective To explore the effect of angelica polysaccharide (AP) on the thymocyte proliferation and RBC C3bR immune adhesion function in radiated mice. Methods Mice were divided into control, irradiated and AP treated also irradiated groups (10 per group). The proliferation of thymocytes and RBC C3bR rosette formation rate were then examined on day 10 after AP was given. Results The thymocyte proliferation responses ( 0.24 ± 0.01 ) and the RBC C3bR rosette formation rate [( 16.46±0.76 )%] of the irradiated control group were significantly lower than those of the non irradiated controls [( 0.35 ± 0.01 ) and ( 22.30 ± 1.26 )%, respectively; P< 0.01 )]. The thymocyte proliferation ( 0.31±0.01 ) and RBC 36bR rosette formation [( 21.07±1.22 )%] in the treatment group were significantly higher (P< 0.01 ) than those of the irradiated control group, and approached non irradiated control levels. Conclusions AP can reverse radiation induced reduction in the proliferation response of thymocytes and in RBC immune adhesion function.

关 键 词：当归多糖 胸腺细胞增殖 红细胞免疫 小鼠 放射损伤 

分 类 号：R285.5[医药卫生—中药学]