养肝熄风方药对帕金森大鼠旋转行为的影响  

Influence of Liver-Nourishing and Wind-Extinguishing Formulas and Drugs on Rotating Behavior in Parkinson Rats

作　　者：陈锡群[1] 蔡定芳[1] 郑振[1] 

机构地区：[1]复旦大学华山医院复旦大学中西医结合研究所,上海200040

出　　处：《上海中医药大学学报》2001年第2期41-43,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：卫生部科研基金资助项目 ( 982 15 1);教育部科研基金资助项目 ( 9747)

摘　　要：为研究养肝熄风方药与左旋多巴联合应用对帕金森模型大鼠神经行为的影响。将 36只帕金森模型大鼠随机分为A、B、C 3组 ,分别以左旋多巴、养肝熄风方药加左旋多巴、生理盐水胃饲 ( 1次 /d) ,持续 12W ,观察其旋转行为的动态变化。结果 :B组动物出现对侧旋转行为 ;旋转总数及旋转强度在 3～ 7W间较A组低 ,11W后则升高 ;旋转时间5W后较A组延长 ;无反应率 4W始较A组减低 (均P <0 0 5 )。说明养肝熄风方药与左旋多巴具有协同作用 。In order to study influence of the combined application of the liver nourishing and wind extinguishing formulas and drugs and levodopa on nervous behavior in the model rats,36 rats modeled with Parkinsons syndrome were divided randomly into three groups of A,B,and C,treated respectively with levodopa,levodopa plus the drugs that nourish the liver and extinguish wind,and physiological saline (once/per day),for 12 weeks continuously,to observe the dynamic change in the rotating behavior.The results showed that the rotating behavior appeared in the opposite side in the animals in Group B.The total rotating activity and rotating intensity were lower than Group A in 3～7 weeks,and increased 11 weeks later.The rotating time was prolonged than Group A five weeks later and no reaction rate was decreased than Group A from the fourth week (all P <0 05).The findings indicate that the herbal formulas and drugs that can nourish the liver and extinguish wind and levodopa possess the cooperative function to relieve the motor complications caused by long term application of levodopa.

关 键 词：帕金森病 左旋多巴 并发症 养肝熄风 神经行为 动物实验 中医药治疗 

分 类 号：R285.5[医药卫生—中药学]