人工软骨(聚乙烯醇水凝胶)与金属基片(或底层骨)的机械-化学连接  

The Mechanical Chemical Attachment of Artificial Cartilage (PVA-Hydrogel) to Metal Substrate (or Underlying Bone)

作　　者：顾正秋[1] 肖久梅[1] 娄思权[2] 

机构地区：[1]北京科技大学材料学院腐蚀系,北京100083 [2]北京医科大学第三临床医院,北京100083

出　　处：《生物医学工程学杂志》2001年第2期185-187,191,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (5 9775 0 38)

摘　　要：聚乙烯醇水凝胶 (PVA- H)具有良好的生物相容性及优良的摩擦学特性 ,但这种人工软骨材料很难与底层骨连接。本研究首先使水凝胶与金属纤维网实现微观机械嵌锁连接 ,然后用骨水泥 (PMMA)将纤维网面与底层骨 (或金属 )粘接。这种方法可实现人工软骨与底层骨 (或金属 )的机械 -化学连接。The biocompatibility and tribological characteristics of PVA-hydrogel are excellent, but it is very difficult to make the artificial cartilage material(PVA-hydrogel) attach to the underlying bone. In this study, PVA-hydrogel is attached to the metal fibre mesh by means of micro-mechanical interlock methods at first, then the surface of metal fibre mesh is bonded to the underlying bone by the bone cement(PMMA). In this way, the artificial cartilage can be firmly attached to the underlying bone (or metal substrate). Microstructure analysis and mechanical tests show that the attachment between artificial cartilage and the metal substrate is firm.

关 键 词：聚乙烯醇水凝胶 复合人工软骨组织 机械-化学连接 

分 类 号：R318.1[医药卫生—生物医学工程]