兔高胆红素血症性脑性瘫痪的病理改变研究  

Pathological study of brain of rabbits with cerebral palsy following hyperbilinemia

作　　者：李晓捷[1] 吴军[1] 孙叶强[1] 李珂静[1] 李永库[1] 姜志梅[1] 

机构地区：[1]黑龙江省小儿脑性瘫痪防治疗育中心,黑龙江佳木斯154002

出　　处：《现代康复》2001年第6期70-70,75,共2页Modern Rehabilitation

摘　　要：目的为探讨高胆红素血症性脑瘫脑组织病理改变特点。方法采用新生仔兔腹腔注射胆红素溶液的方法制备脑瘫动物模型。结果腹腔注射胆红素300mg/kg组仔兔，血清总胆红素浓度明显高于正常对照组(P< 0.01)。可有不自主运动，肌张力异常等中枢性运动障碍和姿势异常等。可见基底节处明显黄染，镜下神经细胞变性、坏死，数量减少，核固缩、形状扭曲，胶质细胞增生等。结论兔高胆红素血症脑瘫的病理改变与人类核黄疸病理改变基本相似。Objective To investigate the pathological characters of brain in cerebral palsy rabbits following hyperbilorunemia.Method Animal models with cerebral palsy was prepared using newborn rabbits with intraperitoneal injection of bilirubin.Result The total bilirubin of serum in experimental group was significantly highter than that in control group(P< 0.01).Animals in experimental group was found the disorder of centrokinectis and abnormal posture such as the involuntary movement or myodystonia.Anatomic research also revealed te basal ganglion is yellow.We also found the nuclear degeneration,neclear distortion and hyperplasia of gliocyte.Conclusion Pathological changes of brain in bilirubin encephalopathy rabbits was similar to that of human nuclear jaundice.

关 键 词：高胆红素血症 胆红素脑病 脑性瘫痪 病理 兔 

分 类 号：R722.17[医药卫生—儿科] R742.3[医药卫生—临床医学]