含聚1,3-二氧戊环链段可降解pH敏感性水凝胶的合成与表征  

STUDY ON DEGRADABLE pH SENSITIVE HYDROGELS CONTAINING POLY(1,3-DIOXOLANE)

作　　者：杜鹃[1] 彭宇行[1] 张婷婷[1] 丁小斌[1] 郑朝辉[1] 张军华[1] 张文传[1] 

机构地区：[1]中国科学院成都有机化学所,成都610041

出　　处：《高分子学报》2001年第4期441-444,共4页Acta Polymerica Sinica

摘　　要：制备了含聚 1,3 二氧戊环链段具有pH敏感性的可解体聚合物凝胶网络 ,网络可在水中及有机溶剂中溶胀 ,且由聚 1,3 二氧戊环构成的水凝胶成分可以在酸性介质中降解 ,使网络解体 .利用红外光谱、色 质联谱等分析手段对聚合物凝胶网络进行了表征 .通过对降解产物的分析 ,一方面证实了降解现象的存在 。A novel pH-sensitive hydrogel was obtained by copolymerization of telechelic poly(1,3-dioxolane) (PDXL) with acrylic acid (AA). The synthesis and swelling properties of networks were discussed. The networks can swell in water and organic solvents. It can swell faster and has higher equilibrium swelling degree in water of pH > 7 than in that of pH < 7. It is due to the easier ionization of -COOH groups in basic solution. In addition to the pH sensitivity, the hydrogels also have special characteristics: the networks containing polyacetal segments (PDXL) can degrade by acid in different solvents. Degraded residues including DXL and few other heterocycles were determined by IR and GC-MS analysis. The result showed that after degradation, linear PDXL segments were broken and became closed cycles in different ways. The intelligent hydrogel prepared has potentials in biosystems such as intelligent drug release systems.

关 键 词：智能型水凝胶 聚1 3-二氧戊环 合成 PH敏感性 表征 降解 

分 类 号：O648[理学—物理化学]