手性噁唑啉-Ti((Ⅳ)配合物催化硫醚的不对称氧化反应研究  

The Asymmetric Oxidation of Sulfides Catalyzed by Chiral Oxazoline-Ti(Ⅳ) Complexes

作　　者：彭云贵[1] 冯小明[2] 崔欣[1] 蒋耀忠[1] 

机构地区：[1]中国科学院成都有机化学研究所不对称合成联合开放实验室,成都610041 [2]四川大学化学学院,成都610064

出　　处：《高等学校化学学报》2001年第8期1326-1331,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 9832 0 2 0 )

摘　　要：设计合成了系列唑啉 -Ti( Oi Pr) 4配合物催化剂 ,首次成功地用这类催化剂催化一系列硫醚的不对称氧化 ,获得了 e.e.值为 70 %～ 96%的亚砜 ;考察了溶剂、催化剂用量。A series of new chiral oxazoline Ti(O i Pr) 4 complexes were synthesized, which were firstly and successfully applied to the catalytic asymmetric oxidation of sulfides and resulted in chiral sulfoxides. The reactivity and enantioselectivity were strongly influenced by the structure of the oxazolines. When (4 S,5S ) 4,5 dihydro 4,5 diphenyl 2 (2 hydroxy 3 tert butylphenyl) oxazoline was used as the ligand, 2.0 mol of TBHP was used in the oxidation of methyl phenyl sulfide, the sulfoxide was obtained in 96% e.e. . The influence of solvent, amount of catalyst, counterion and other conditions on the reaction was also investigated.

关 键 词：催化 硫醚 不对称氧化 手性恶唑啉 钛配合物 催剂 

分 类 号：O623.82[理学—有机化学] O643.36[理学—化学]