龙葵醛的新合成方法研究  

A Novel Synthetic Method of Hydratropic Aldehyde

作　　者：史真[1] 卢林刚[1] 王云侠[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《高等学校化学学报》2001年第8期1352-1354,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 9872 0 32 );陕西省自然科学基金 (批准号 :F F982 134)

摘　　要：Based on the one carbon unit transfer reaction of tetrahydrofolate coenzymes, hydratropic aldehyde was synthesized successfully by using benzimidazolium salt as tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transfered. A novel method for the preparation of hydratropic aldehyde was provided. The mechanism for the addition hydrolysis reaction of benzimidazolium salt with Grignard reagent and the effects of reaction condition on the yield are discussed.Based on the one carbon unit transfer reaction of tetrahydrofolate coenzymes, hydratropic aldehyde was synthesized successfully by using benzimidazolium salt as tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transfered. A novel method for the preparation of hydratropic aldehyde was provided. The mechanism for the addition hydrolysis reaction of benzimidazolium salt with Grignard reagent and the effects of reaction condition on the yield are discussed.

关 键 词：龙葵醛 苯并咪唑盐 GRIGNARD试剂 有机合成 

分 类 号：O625.41[理学—有机化学]